(S)-2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl 4-methylbenzenesulfonate

Base Information

Chemical Name:(S)-2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl 4-methylbenzenesulfonate
CAS No.:1643461-37-3
Molecular Formula:C₂₉H₄₃NO₆S
Molecular Weight:533.73
Hs Code.:

Synonyms:(S)-2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl 4-methylbenzenesulfonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl 4-methylbenzenesulfonate

Chemical Property:

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Technology Process of (S)-2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl 4-methylbenzenesulfonate

There total 5 articles about (S)-2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1643461-36-2
(R)-tert-butyl [1-hydroxy-3-(4-octylphenoxy)propan-2-yl]carbamate

: 98-59-9
p-toluenesulfonyl chloride

: 1643461-37-3
(S)-2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl 4-methylbenzenesulfonate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1039/c4ob00535j

Reference yield:

: 108149-60-6,95715-86-9
methyl [(4R)-3-(tert-butoxycarbonyl)-2,2-dimethyl-1,3-oxazolidin-4-yl]carboxylate

: 1643461-37-3
(S)-2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium borohydride / tetrahydrofuran / 3 h / 0 °C

2.1: dmap; triethylamine / dichloromethane / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

3.2: 3 h / 70 °C

4.1: toluene-4-sulfonic acid / methanol / 4 h / 20 °C

5.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C

With dmap; lithium borohydride; sodium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c4ob00535j

Reference yield:

: 205647-74-1
(R)-tert-butyl 2,2-dimethyl-4-[(tosyloxy)methyl]-oxazolidine-3-carboxylate

: 1643461-37-3
(S)-2-[(tert-butoxycarbonyl)amino]-3-(4-octylphenoxy)propyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

1.2: 3 h / 70 °C

2.1: toluene-4-sulfonic acid / methanol / 4 h / 20 °C

3.1: dmap; triethylamine / dichloromethane / 12 h / 20 °C

With dmap; sodium hydride; toluene-4-sulfonic acid; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c4ob00535j