(S)-3-Amino-3-(2-nitro-phenyl)-propionic acid

Base Information

• Chemical Name: (S)-3-Amino-3-(2-nitro-phenyl)-propionic acid
• CAS No.: 732242-02-3
• Molecular Formula: C₉H₁₀N₂O₄
• Molecular Weight: 210.189
• Mol file: 732242-02-3.mol

Synonyms:(S)-3-(2-NITROPHENYL)-BETA-ALANINE ;H-b-Phe(2-NO2)-OH

Chemical Property of (S)-3-Amino-3-(2-nitro-phenyl)-propionic acid

Chemical Property:

• Boiling Point: 423.8±35.0 °C(Predicted)
• PKA: 3.49±0.10(Predicted)
• PSA: 109.14000
• Density: 1.404±0.06 g/cm3(Predicted)
• LogP: 2.29280
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98%min ^*data from raw suppliers

(S)-3-Amino-3-(2-nitrophenyl)propanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-3-Amino-3-(2-nitro-phenyl)-propionic acid

There total 15 articles about (S)-3-Amino-3-(2-nitro-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

malonic acid (141-82-2) + 2-nitro-benzaldehyde (552-89-6) → 3-amino-3-(2-nitrophenyl)propionic acid (5678-48-8,732242-02-3,756814-14-9)

Guidance literature:

With ammonium acetate; In butan-1-ol; Reflux;

DOI:10.1016/j.ejmech.2018.07.005

Reference yield: 45.0%

malonic acid (141-82-2) + 2-nitro-benzaldehyde (552-89-6) → 3-amino-3-(2-nitrophenyl)propionic acid (5678-48-8,732242-02-3,756814-14-9) + 3-(2-nitrophenyl)-2-carboxy-2-propenoic acid (103582-31-6)

Guidance literature:

With ammonium acetate; In butan-1-ol; Heating;

DOI:10.1007/s11176-005-0377-9

Reference yield: 40.0%

malonic acid (141-82-2) + 2-nitro-benzaldehyde (552-89-6) → 3-amino-3-(2-nitrophenyl)propionic acid (5678-48-8,732242-02-3,756814-14-9) + 3-N-Acetyl-amino-3-(o-nitrophenyl)-propionsaeure (103582-32-7) + 2-nitrocinnamic acid (612-41-9)

Guidance literature:

With ammonium acetate; In acetic acid; at 100 ℃; for 5h;

DOI:10.1002/ardp.19863190603

upstream raw materials:

ethanol

3-hydroxyamino-3-(2-nitro-phenyl)-propionohydroxamic acid

ethyl 3-(2-nitrophenyl)acrylate

malonic acid

Downstream raw materials:

3-(2-amino-acetylamino)-3-(2-nitrophenyl)-N-pyridin-2-ylmethyl-propionamide

Refernces

• 1、 ?kach, Kry?tof,Dostálková, Al?běta,Flegel, Martin,Hadravová, Romana,Hrabal, Richard,K?í?ová, Ivana,Kaufman, Filip,Ruml, Tomá?,Rumlová, Michaela. "PF74 and its novel derivatives stabilize hexameric lattice of HIV-1 mature-like particles". . . Retrieved 2020/04/27.
• 2、 Weise, Nicholas J.,Ahmed, Syed T.,Parmeggiani, Fabio,Turner, Nicholas J.. "Kinetic Resolution of Aromatic β-Amino Acids Using a Combination of Phenylalanine Ammonia Lyase and Aminomutase Biocatalysts". . p. 1570 - 1576. Retrieved 2017/05/05.