(E)-Ethyl 3-(2-nitrophenyl)acrylate

Base Information

• Chemical Name: (E)-Ethyl 3-(2-nitrophenyl)acrylate
• CAS No.: 2437-05-0
• Molecular Formula: C₁₁H₁₁NO₄
• Molecular Weight: 221.213
• NSC Number: 38000
• Nikkaji Number: J136.419G,J882.305G
• Mol file: 2437-05-0.mol

Synonyms:(E)-Ethyl 3-(2-nitrophenyl)acrylate;24393-59-7;2437-05-0;Ethyl 3-(2-nitrophenyl)acrylate;ethyl (E)-3-(2-nitrophenyl)prop-2-enoate;Ethyl o-nitrocinnamate;2-Nitrobenzeneacrylic acid ethyl ester;2-Propenoic acid, 3-(2-nitrophenyl)-, ethyl ester;NSC38000;Ethyl 2-nitrocinnamicacid;SCHEMBL4688054;Ethyl3-(2-nitrophenyl)acrylate;NIOSH/GE0353166;2-Nitrocinnamic acid ethyl ester;ZAA39359;MFCD00956801;NSC-38000;(E)-Ethyl-3-(2-nitrophenyl)acrylate;AKOS024385936;Cinnamic acid, o-nitro-, ethyl ester;BS-32174;GE03531660;ETHYL (E)-3-(2-NITROPHENYL)ACRYLATE;W17921;Ethyl (2E)-3-(2-nitrophenyl)-2-propenoate #

Chemical Property of (E)-Ethyl 3-(2-nitrophenyl)acrylate

Chemical Property:

• Vapor Pressure: 3.16E-05mmHg at 25°C
• Boiling Point: 355.3°Cat760mmHg
• Flash Point: 160.1°C
• PSA: 72.12000
• Density: 1.237g/cm³
• LogP: 2.69430
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 221.06880783
• Heavy Atom Count: 16
• Complexity: 282

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C=CC1=CC=CC=C1[N+](=O)[O-]
• Isomeric SMILES: CCOC(=O)/C=C/C1=CC=CC=C1[N+](=O)[O-]

Technology Process of (E)-Ethyl 3-(2-nitrophenyl)acrylate

There total 15 articles about (E)-Ethyl 3-(2-nitrophenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethanol (64-17-5) + 2-nitrocinnamic acid (612-41-9) → ethyl 3-(2-nitrophenyl)acrylate (2437-05-0,24393-59-7,94527-24-9)

Guidance literature:

With sulfuric acid; at 90 ℃; for 2h;

Reference yield: 99.0%

2-nitro-benzaldehyde (552-89-6) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → ethyl 3-(2-nitrophenyl)acrylate (2437-05-0,24393-59-7,94527-24-9)

Guidance literature:

In tetrahydrofuran;

DOI:10.1055/s-2004-830868

Reference yield: 95.0%

2-nitrophenyl bromide (577-19-5) + ethyl acrylate (140-88-5,9003-32-1) → ethyl 3-(2-nitrophenyl)acrylate (2437-05-0,24393-59-7,94527-24-9)

Guidance literature:

With potassium phosphate; [((ferrocenyl)(C(CH₃)N(C₆H₄)CH₃))PdCl(N,N'-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)]; tetrabutylammomium bromide; In N,N-dimethyl-formamide; at 140 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.tet.2010.04.040

upstream raw materials:

ethyl 3-phenyl-2-propenoate

ethyl cinnamate

nitric acid

hydrogen ethyl malonate

Downstream raw materials:

3-(2-nitrophenyl)prop-2-en-1-ol

4-benzyl-3H-pyrrolo[2,3-c]quinoline

2-carbethoxyindole

ethyl 2,3-dihydro-2-oxo-1H-indole-3-acetate