N'-Benzyl-N'-[(2R,3R)-3-benzyloxycarbonylamino-4-phenyl-2-(2-trimethylsilanyl-ethoxymethoxy)-butyl]-hydrazinecarboxylic acid benzyl ester

Base Information

Chemical Name:N'-Benzyl-N'-[(2R,3R)-3-benzyloxycarbonylamino-4-phenyl-2-(2-trimethylsilanyl-ethoxymethoxy)-butyl]-hydrazinecarboxylic acid benzyl ester
CAS No.:173261-24-0
Molecular Formula:C₃₉H₄₉N₃O₆Si
Molecular Weight:683.92
Hs Code.:

Synonyms:N'-Benzyl-N'-[(2R,3R)-3-benzyloxycarbonylamino-4-phenyl-2-(2-trimethylsilanyl-ethoxymethoxy)-butyl]-hydrazinecarboxylic acid benzyl ester

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Chemical Property of N'-Benzyl-N'-[(2R,3R)-3-benzyloxycarbonylamino-4-phenyl-2-(2-trimethylsilanyl-ethoxymethoxy)-butyl]-hydrazinecarboxylic acid benzyl ester

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Technology Process of N'-Benzyl-N'-[(2R,3R)-3-benzyloxycarbonylamino-4-phenyl-2-(2-trimethylsilanyl-ethoxymethoxy)-butyl]-hydrazinecarboxylic acid benzyl ester

There total 9 articles about N'-Benzyl-N'-[(2R,3R)-3-benzyloxycarbonylamino-4-phenyl-2-(2-trimethylsilanyl-ethoxymethoxy)-butyl]-hydrazinecarboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 178059-31-9
N'-Benzyl-N'-((2R,3R)-3-benzyloxycarbonylamino-2-hydroxy-4-phenyl-butyl)-hydrazinecarboxylic acid benzyl ester

: 173261-24-0
N'-Benzyl-N'-[(2R,3R)-3-benzyloxycarbonylamino-4-phenyl-2-(2-trimethylsilanyl-ethoxymethoxy)-butyl]-hydrazinecarboxylic acid benzyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 19h; Ambient temperature;
DOI:10.1021/jm9507183

Reference yield:

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 173261-24-0
N'-Benzyl-N'-[(2R,3R)-3-benzyloxycarbonylamino-4-phenyl-2-(2-trimethylsilanyl-ethoxymethoxy)-butyl]-hydrazinecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

2: 83 percent / diisopropylethylamine / dimethylformamide / 19 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm9507183

Reference yield:

: 63219-70-5
N-(benzyloxycarbonyl)-D-phenylalaninal

: 173261-24-0
N'-Benzyl-N'-[(2R,3R)-3-benzyloxycarbonylamino-4-phenyl-2-(2-trimethylsilanyl-ethoxymethoxy)-butyl]-hydrazinecarboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: toluene / 1.) -78 deg C, 2 h 2.) RT, 0.5 h

2: 2.7 g / m-chloroperbenzoic acid / CH₂Cl₂ / Ambient temperature

3: 72 percent / propan-2-ol / 24 h / Heating

4: trifluoroacetic acid / CH₂Cl₂

6: 83 percent / diisopropylethylamine / dimethylformamide / 19 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; toluene;
DOI:10.1021/jm9507183