4-Methoxy-benzoic acid (3S,4R)-3-hydroxy-4-(4-hydroxy-phenylsulfanyl)-tetrahydro-pyran-3-ylmethyl ester

Base Information

Chemical Name:4-Methoxy-benzoic acid (3S,4R)-3-hydroxy-4-(4-hydroxy-phenylsulfanyl)-tetrahydro-pyran-3-ylmethyl ester
CAS No.:841255-59-2
Molecular Formula:C₂₀H₂₂O₆S
Molecular Weight:390.457
Hs Code.:

Synonyms:4-Methoxy-benzoic acid (3S,4R)-3-hydroxy-4-(4-hydroxy-phenylsulfanyl)-tetrahydro-pyran-3-ylmethyl ester

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Chemical Property of 4-Methoxy-benzoic acid (3S,4R)-3-hydroxy-4-(4-hydroxy-phenylsulfanyl)-tetrahydro-pyran-3-ylmethyl ester

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Technology Process of 4-Methoxy-benzoic acid (3S,4R)-3-hydroxy-4-(4-hydroxy-phenylsulfanyl)-tetrahydro-pyran-3-ylmethyl ester

There total 4 articles about 4-Methoxy-benzoic acid (3S,4R)-3-hydroxy-4-(4-hydroxy-phenylsulfanyl)-tetrahydro-pyran-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-07-2
4-methoxy-benzoyl chloride

: 841255-59-2
4-Methoxy-benzoic acid (3S,4R)-3-hydroxy-4-(4-hydroxy-phenylsulfanyl)-tetrahydro-pyran-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / Et₃N; DMAP / CH₂Cl₂

2: 90 percent / (DHQ)2PHAL; aq. K₂OsO₄; K₃Fe(CN)6 / K₂CO₃ / 2-methyl-propan-2-ol

3: SOCl₂; Et₃N / CH₂Cl₂

4: RuCl₃; aq. NaIO₄ / CCl₄; acetonitrile

5: 93 percent / NaH / dimethylformamide / Heating

With dmap; ruthenium trichloride; potassium osmate(VI); sodium periodate; thionyl chloride; Hydroquinone 1,4-phthalazinediyl diether; sodium hydride; triethylamine; potassium hexacyanoferrate(III); potassium carbonate; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2004.06.081

Reference yield:

: 756533-15-0
4-methoxy-benzoic acid 5,6-dihydro-2H-pyran-3-ylmethyl ester

: 841255-59-2
4-Methoxy-benzoic acid (3S,4R)-3-hydroxy-4-(4-hydroxy-phenylsulfanyl)-tetrahydro-pyran-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / (DHQ)2PHAL; aq. K₂OsO₄; K₃Fe(CN)6 / K₂CO₃ / 2-methyl-propan-2-ol

2: SOCl₂; Et₃N / CH₂Cl₂

3: RuCl₃; aq. NaIO₄ / CCl₄; acetonitrile

4: 93 percent / NaH / dimethylformamide / Heating

With ruthenium trichloride; potassium osmate(VI); sodium periodate; thionyl chloride; Hydroquinone 1,4-phthalazinediyl diether; sodium hydride; triethylamine; potassium hexacyanoferrate(III); potassium carbonate; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2004.06.081

Reference yield:

: 756533-16-1
4-Methoxy-benzoic acid (3S,4S)-3,4-dihydroxy-tetrahydro-pyran-3-ylmethyl ester

: 841255-59-2
4-Methoxy-benzoic acid (3S,4R)-3-hydroxy-4-(4-hydroxy-phenylsulfanyl)-tetrahydro-pyran-3-ylmethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂; Et₃N / CH₂Cl₂

2: RuCl₃; aq. NaIO₄ / CCl₄; acetonitrile

3: 93 percent / NaH / dimethylformamide / Heating

With ruthenium trichloride; sodium periodate; thionyl chloride; sodium hydride; triethylamine; In tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2004.06.081