Ethanone, 1-[4-(hydroxymethyl)phenyl]- (9CI)

Base Information

• Chemical Name: Ethanone, 1-[4-(hydroxymethyl)phenyl]- (9CI)
• CAS No.: 75633-63-5
• Molecular Formula: C9H10 O2
• Molecular Weight: 150.177
• Hs Code.: 2914400090
• Mol file: 75633-63-5.mol

Synonyms:1-(4-Hydroxymethylphenyl)ethanone;4-(Hydroxymethyl)acetophenone; 4-Acetylbenzyl alcohol;4'-Hydroxymethylacetophenone; p-Acetylbenzyl alcohol

Chemical Property of Ethanone, 1-[4-(hydroxymethyl)phenyl]- (9CI)

Chemical Property:

• Melting Point: 54 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 301℃
• PKA: 13.94±0.10(Predicted)
• Flash Point: 127℃
• PSA: 37.30000
• Density: 1.114
• LogP: 1.38150
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%Min ^*data from raw suppliers

1-(4-(Hydroxymethyl)phenyl)ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-[4-(hydroxymethyl)phenyl]- (9CI)

There total 51 articles about Ethanone, 1-[4-(hydroxymethyl)phenyl]- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-methylquinoline (91-63-4) + p-formylacetophenone (3457-45-2) → 4-(hydroxymethyl)acetophenone (75633-63-5) + 1,2,3,4-tetrahydro-2-methylquinoline (1780-19-4)

Guidance literature:

With (7,8-benzoquinolinato)hydrido(aqua)bis(triphenylphosphine)iridium(III) tetrakis[3,5-bis(trifluoromethyl)phenyl]borate; hydrogen; In toluene; at 80 ℃; for 18h;

DOI:10.1021/om400267n

Reference yield: 98.7%

p-formylacetophenone (3457-45-2) → 4-(hydroxymethyl)acetophenone (75633-63-5)

Guidance literature:

With sodium tetrahydroborate; In ethanol; for 5h;

DOI:10.1016/j.tetlet.2006.05.157

Reference yield: 98.0%

4-(1-hydroxyethyl)benzyl alcohol (80463-22-5) → 4-(hydroxymethyl)acetophenone (75633-63-5) + 4-(1-hydroxyethyl)benzaldehyde (80463-21-4)

Guidance literature:

With hydrotalcite; RuMn₂; oxygen; In toluene; at 60 ℃; atmospheric pressure;

DOI:10.1002/anie.200462600

upstream raw materials:

1-(4-hydroxymethyl-phenyl)-ethanone-diethylacetal

p-formylacetophenone

4-(1-hydroxyethyl)benzyl alcohol

para-bromoacetophenone

Downstream raw materials:

4-{3-[2-(2-methoxy-ethoxymethoxy)-phenyl]-acryloyl}-benzyl alcohol

(-)-1-(4-hydroxymethylphenyl)ethanol

2-(4-acetylphenyl)acetonitrile

4-acetyl-phenylacetic acid