Technology Process of (S,S)-γ-amino-β-hydroxy-N-<2-(4-morpholinyl)ethyl>cyclohexane pentanamide
There total 9 articles about (S,S)-γ-amino-β-hydroxy-N-<2-(4-morpholinyl)ethyl>cyclohexane pentanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1) N,N'-carbonyldiimidazole / 1) tetrahydrofuran, 30 min, 2) tetrahydrofuran, dimethyl sulfoxide, 4h, room temp.
2: 97 percent / H2 / RuBr2<(R)-binap> / ethanol / 145 h / 20 °C / 76000.1 Torr
3: 96 percent / aq. potassium hydroxide / dioxane / 8 h / 0 °C
4: H2 / 5percent Rh-Al2O3 / ethanol / 16 h / 3040 - 3800 Torr
5: 96 percent / DEPC, triethylamine / tetrahydrofuran / 6 h / 0 °C
6: 4N HCl / dioxane / 0.5 h / Ambient temperature
With
hydrogenchloride; potassium hydroxide; hydrogen; triethylamine; diethyl dicarbonate; 1,1'-carbonyldiimidazole;
[(R)-BINAP]RuBr2; rhodium on alumina;
In
tetrahydrofuran; 1,4-dioxane; ethanol;
DOI:10.1248/cpb.38.103
- Guidance literature:
-
Multi-step reaction with 3 steps
1: H2 / 5percent Rh-Al2O3 / ethanol / 16 h / 3040 - 3800 Torr
2: 96 percent / DEPC, triethylamine / tetrahydrofuran / 6 h / 0 °C
3: 4N HCl / dioxane / 0.5 h / Ambient temperature
With
hydrogenchloride; hydrogen; triethylamine; diethyl dicarbonate;
rhodium on alumina;
In
tetrahydrofuran; 1,4-dioxane; ethanol;
DOI:10.1248/cpb.38.103
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 96 percent / aq. potassium hydroxide / dioxane / 8 h / 0 °C
2: H2 / 5percent Rh-Al2O3 / ethanol / 16 h / 3040 - 3800 Torr
3: 96 percent / DEPC, triethylamine / tetrahydrofuran / 6 h / 0 °C
4: 4N HCl / dioxane / 0.5 h / Ambient temperature
With
hydrogenchloride; potassium hydroxide; hydrogen; triethylamine; diethyl dicarbonate;
rhodium on alumina;
In
tetrahydrofuran; 1,4-dioxane; ethanol;
DOI:10.1248/cpb.38.103
