tert-butyl 3-(((4'-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)methyl)(methyl)amino)-3-oxopropylcarbamate

Base Information

Chemical Name:tert-butyl 3-(((4'-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)methyl)(methyl)amino)-3-oxopropylcarbamate
CAS No.:1338327-09-5
Molecular Formula:C₂₉H₃₃ClN₆O₅
Molecular Weight:581.071
Hs Code.:

Synonyms:tert-butyl 3-(((4'-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)methyl)(methyl)amino)-3-oxopropylcarbamate

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Chemical Property of tert-butyl 3-(((4'-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)methyl)(methyl)amino)-3-oxopropylcarbamate

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Technology Process of tert-butyl 3-(((4'-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)methyl)(methyl)amino)-3-oxopropylcarbamate

There total 11 articles about tert-butyl 3-(((4'-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)methyl)(methyl)amino)-3-oxopropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1338326-84-3
4-amino-6-(4-bromophenyl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one

: 1338327-10-8
tert-butyl 3-((3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)(methyl)amino)-3-oxopropylcarbamate

: 1338327-09-5
tert-butyl 3-(((4'-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)methyl)(methyl)amino)-3-oxopropylcarbamate

Guidance literature:: With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In methanol; 1,2-dimethoxyethane; water; at 110 ℃; for 0.666667h; Microwave irradiation; Sealed tube; Inert atmosphere;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1338327-09-5
tert-butyl 3-(((4'-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)methyl)(methyl)amino)-3-oxopropylcarbamate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium carbonate / N,N-dimethyl-formamide / 72 h / 60 °C / Inert atmosphere

2: triethylamine / tetrahydrofuran / 2.02 h / 0 °C / Inert atmosphere

3: hydrogenchloride / methanol / 0.5 h / 18 - 25 °C / Inert atmosphere

4: triethylamine / acetonitrile / 6 h / 80 °C / Inert atmosphere

5: ammonia / 1,4-dioxane / 20 - 45 °C

6: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water; methanol / 0.67 h / 110 °C / Microwave irradiation; Sealed tube; Inert atmosphere

With hydrogenchloride; potassium phosphate; ammonia; sodium carbonate; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; acetonitrile; 6: Suzuki Coupling;

Reference yield:

: 120077-69-2
3-chloro4-bromo-benzaldehyde

: 1338327-09-5
tert-butyl 3-(((4'-(4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)-2-chlorobiphenyl-4-yl)methyl)(methyl)amino)-3-oxopropylcarbamate

Guidance literature:: Multi-step reaction with 5 steps

1: acetic acid; sodium tris(acetoxy)borohydride / tetrahydrofuran / 4 h / 18 - 25 °C / Inert atmosphere

2: sodium tetrahydroborate / methanol / 2 h / 18 - 25 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 h / 18 - 25 °C / Inert atmosphere

4: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.75 h / 120 °C / Microwave irradiation; Sealed tube; Inert atmosphere

5: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water; methanol / 0.67 h / 110 °C / Microwave irradiation; Sealed tube; Inert atmosphere

With sodium tetrahydroborate; potassium phosphate; potassium acetate; sodium tris(acetoxy)borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 5: Suzuki Coupling;