1338326-84-3Relevant articles and documents
Discovery and optimization of efficacious neutral 4-amino-6-biphenyl-7,8- dihydropyrimido[5,4-f][1,4]oxazepin-5-one diacylglycerol acyl transferase-1 (DGAT1) inhibitors
Goldberg, Frederick W.,Birch, Alan M.,Leach, Andrew G.,Groombridge, Sam D.,Snelson, Wendy L.,Gutierrez, Pablo Morentin,Hammond, Clare D.,Birtles, Susan,Buckett, Linda K.
, p. 165 - 174 (2013/03/14)
A series of neutral DGAT1 inhibitors with good potency and pharmacokinetics (PK) has been designed by modification of an acidic startpoint. This was achieved by selecting the acid with the highest ligand lipophilicity efficiency (LLE) and replacing the ac