4-(2-Bromo-4,6-dimethoxyphenyl)amino-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)pyrimidine

Base Information

Chemical Name:4-(2-Bromo-4,6-dimethoxyphenyl)amino-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)pyrimidine
CAS No.:219840-93-4
Molecular Formula:C₂₀H₁₆BrF₃N₄O₄
Molecular Weight:513.271
Hs Code.:

Synonyms:4-(2-Bromo-4,6-dimethoxyphenyl)amino-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)pyrimidine

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Chemical Property of 4-(2-Bromo-4,6-dimethoxyphenyl)amino-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)pyrimidine

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Technology Process of 4-(2-Bromo-4,6-dimethoxyphenyl)amino-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)pyrimidine

There total 3 articles about 4-(2-Bromo-4,6-dimethoxyphenyl)amino-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 2-bromo-4,6-dimethoxyaniline

: 199728-08-0
4-Chloro-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)-pyrimidine

: 219840-93-4
4-(2-Bromo-4,6-dimethoxyphenyl)amino-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)pyrimidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; Heating;
DOI:10.1016/S0960-894X(99)00133-X

Reference yield:

: 1423-27-4
2-(trifluoromethyl)phenylboronic acid

: 219840-93-4
4-(2-Bromo-4,6-dimethoxyphenyl)amino-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / (Ph₃P)4Pd, 1M aq. Na₂CO₃ / benzene / Heating

2: 79 percent / diisopropylethylamine / dioxane / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; benzene;
DOI:10.1016/S0960-894X(99)00133-X

Reference yield:

: 392-83-6
o-trifluoromethylphenyl bromide

: 219840-93-4
4-(2-Bromo-4,6-dimethoxyphenyl)amino-2-methyl-5-nitro-6-(2-(trifluoromethyl)phenyl)pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: n-butyllithium / tetrahydrofuran

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethyl acetate; benzene

3: N-ethyl-N,N-diisopropylamine / 1,4-dioxane; ethyl acetate

With n-butyllithium; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; benzene;