N-[(3-Fluoro-4-nitro-benzylcarbamoyl)-methyl]-3-(4-hydroxy-phenyl)-propionamide

Base Information

Chemical Name:N-[(3-Fluoro-4-nitro-benzylcarbamoyl)-methyl]-3-(4-hydroxy-phenyl)-propionamide
CAS No.:160538-49-8
Molecular Formula:C₁₈H₁₈FN₃O₅
Molecular Weight:375.356
Hs Code.:

Synonyms:N-[(3-Fluoro-4-nitro-benzylcarbamoyl)-methyl]-3-(4-hydroxy-phenyl)-propionamide

Suppliers and Price of N-[(3-Fluoro-4-nitro-benzylcarbamoyl)-methyl]-3-(4-hydroxy-phenyl)-propionamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-[(3-Fluoro-4-nitro-benzylcarbamoyl)-methyl]-3-(4-hydroxy-phenyl)-propionamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-[(3-Fluoro-4-nitro-benzylcarbamoyl)-methyl]-3-(4-hydroxy-phenyl)-propionamide

There total 5 articles about N-[(3-Fluoro-4-nitro-benzylcarbamoyl)-methyl]-3-(4-hydroxy-phenyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 3850-43-9
N-[3-(4-hydroxy-phenyl)-propionyl]-glycine

: 160538-52-3
3-Fluoro-4-nitro-benzylamine

: 160538-49-8
N-[(3-Fluoro-4-nitro-benzylcarbamoyl)-methyl]-3-(4-hydroxy-phenyl)-propionamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; for 12h; Ambient temperature;
DOI:10.1016/S0040-4039(00)74434-0

Reference yield:

: 501-97-3
4-hydroxyphenylpropionic acid

: 160538-49-8
N-[(3-Fluoro-4-nitro-benzylcarbamoyl)-methyl]-3-(4-hydroxy-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / N,N-dicyclohexyl carbodiimide, 1-hydroxy benzotriazole / dimethylformamide / 12 h / Ambient temperature

2: 92 percent / hydrogen / Pd-C / ethyl acetate / 2 h

3: 82 percent / dicyclohexyl carbodiimide, 1-hydroxy benzotriazole / dimethylformamide / 12 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74434-0

Reference yield:

: 160538-48-7
[3-(4-Hydroxy-phenyl)-propionylamino]-acetic acid benzyl ester

: 160538-49-8
N-[(3-Fluoro-4-nitro-benzylcarbamoyl)-methyl]-3-(4-hydroxy-phenyl)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / hydrogen / Pd-C / ethyl acetate / 2 h

2: 82 percent / dicyclohexyl carbodiimide, 1-hydroxy benzotriazole / dimethylformamide / 12 h / Ambient temperature

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74434-0