1-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide

Base Information

• Chemical Name: 1-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide
• CAS No.: 1257521-37-1
• Molecular Formula: C₁₂H₈F₇NO
• Molecular Weight: 315.19
• Mol file: 1257521-37-1.mol

Synonyms:1-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide

Chemical Property of 1-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide

There total 2 articles about 1-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methylcyclopropanecarbonyl chloride (16480-05-0) + 4-trifluoromethyl-2,3,5,6-tetrafluoroaniline (651-83-2) → 1-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide (1257521-37-1)

Guidance literature:

In toluene; for 12h; Reflux;

DOI:10.1021/ja108754f

Reference yield:

1-Methyl-cyclopropanoic acid (6914-76-7) → 1-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide (1257521-37-1)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere

2: toluene / 12.5 h / 20 °C / Reflux

With oxalyl dichloride; In dichloromethane; toluene;

DOI:10.1002/anie.201509996

Reference yield: 86.0%

carbon monoxide (201230-82-2) + 1-methyl-N-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)cyclopropane-1-carboxamide (1257521-37-1) → 1-methyl-3-(2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenyl)-3-azabicyclo[3.1.0]hexane-2,5-dione

Guidance literature:

With potassium dihydrogenphosphate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; silver(I) acetate; palladium diacetate; In hexane; at 130 ℃; for 18h; under 760.051 Torr;

DOI:10.1021/ja108754f

upstream raw materials:

1-methylcyclopropanecarbonyl chloride

4-trifluoromethyl-2,3,5,6-tetrafluoroaniline

1-Methyl-cyclopropanoic acid

Downstream raw materials:

C₂₄H₁₆F₇NO