1H-Pyrrolo[2,3-c]pyridine-7-carbonitrile,2,3-dihydro-5-methoxy-(9CI)

Base Information

• Chemical Name: 1H-Pyrrolo[2,3-c]pyridine-7-carbonitrile,2,3-dihydro-5-methoxy-(9CI)
• CAS No.: 727993-76-2
• Molecular Formula: C9H9 N3 O
• Molecular Weight: 175.19
• Mol file: 727993-76-2.mol

Synonyms:5-Methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-7-carbonitrile

Chemical Property of 1H-Pyrrolo[2,3-c]pyridine-7-carbonitrile,2,3-dihydro-5-methoxy-(9CI)

Chemical Property:

• PSA: 57.94000
• LogP: 1.06788

Purity/Quality:

97% ^*data from raw suppliers

2,3-dihydro-5-methoxy-1H-Pyrrolo[2,3-c]pyridine-7-carbonitrile 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[2,3-c]pyridine-7-carbonitrile,2,3-dihydro-5-methoxy-(9CI)

There total 9 articles about 1H-Pyrrolo[2,3-c]pyridine-7-carbonitrile,2,3-dihydro-5-methoxy-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

zinc(II) cyanide (557-21-1) + 7-bromo-5-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine (727993-75-1) → 5-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-7-carbonitrile (727993-76-2)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In N,N-dimethyl-formamide; at 130 ℃;

DOI:10.1016/j.tetlet.2011.08.009

Reference yield: 74.0%

dicyanozinc (557-21-1) + 7-bromo-5-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine (727993-75-1) → 5-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-7-carbonitrile (727993-76-2)

Guidance literature:

With 1,1'-bis-(diphenylphosphino)ferrocene; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2004.03.067

Reference yield: 54.0%

copper(l) cyanide + 7-bromo-5-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine (727993-75-1) → 5-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-7-carbonitrile (727993-76-2)

Guidance literature:

In N,N-dimethyl-formamide; Microwave irradiation;

DOI:10.1016/j.tetlet.2011.08.009

upstream raw materials:

dicyanozinc

7-bromo-5-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine

6-methoxy-pyridin-3-ylamine

tert-butyl N-(6-methoxypyridin-3-yl)carbamate

Downstream raw materials:

5-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridin-7-yl(phenyl)methanone

N-(4-methoxy-9-oxo-6-phenyl-1,2,8,9-tetrahydro-5,7,9a-triaza-benzo[cd]azulen-8-yl)-nicotinamide

8-azido-4-methoxy-6-phenyl-1,2-dihydro-8H-5,7,9a-triaza-benzo [cd] azulen-9-one

8-Amino-4-methoxy-6-phenyl-1,2-dihydro-8H-5,7,9a-triaza-benzo[cd]azulen-9-one

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