Methanone, (2,3-dihydro-5-methoxy-1H-pyrrolo[2,3-c]pyridin-7-yl)phenyl-

Base Information

Chemical Name:Methanone, (2,3-dihydro-5-methoxy-1H-pyrrolo[2,3-c]pyridin-7-yl)phenyl-
CAS No.:727993-77-3
Molecular Formula:C15H14N2O2
Molecular Weight:254.288
Hs Code.:

Synonyms:(5-methoxy-2,3-dihydro-1H pyrrolo-[2,3-c]pyridin-7-yl)-phenyl methanone;(5-Methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridin-7-yl)-phenyl-methanone;5-methoxy-7-benzoyl-6-azaindoline;

Suppliers and Price of Methanone, (2,3-dihydro-5-methoxy-1H-pyrrolo[2,3-c]pyridin-7-yl)phenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methanone, (2,3-dihydro-5-methoxy-1H-pyrrolo[2,3-c]pyridin-7-yl)phenyl-

Chemical Property:

PSA：51.22000
LogP:2.42720

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of Methanone, (2,3-dihydro-5-methoxy-1H-pyrrolo[2,3-c]pyridin-7-yl)phenyl-

There total 8 articles about Methanone, (2,3-dihydro-5-methoxy-1H-pyrrolo[2,3-c]pyridin-7-yl)phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 100-58-3
phenylmagnesium bromide

: 727993-76-2
5-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-7-carbonitrile

: 727993-77-3
5-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridin-7-yl(phenyl)methanone

Guidance literature:: phenylmagnesium bromide; 5-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-7-carbonitrile; In tetrahydrofuran; at -5 - 20 ℃; for 0.25h;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate; pH=1;

Reference yield: 55.0%

: phenylmagnesium bromide

: 727993-76-2
5-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine-7-carbonitrile

: 727993-77-3
5-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridin-7-yl(phenyl)methanone

Guidance literature:: In tetrahydrofuran;
DOI:10.1016/j.bmcl.2004.03.067

Reference yield:

: 6628-77-9
6-methoxy-pyridin-3-ylamine

: 727993-77-3
5-methoxy-2,3-dihydro-1H-pyrrolo[2,3-c]pyridin-7-yl(phenyl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / dioxane

2: 57 percent / n-BuLi; TMEDA / diethyl ether / -78 °C

3: 90 percent / CH₂Cl₂

4: 91 percent / LiHMDS / tetrahydrofuran / -78 °C

5: 75 percent / HBr; aq. H₂O₂

6: 74 percent / Pd₂(dba)3; dppf / dimethylformamide

7: 55 percent / tetrahydrofuran

With 1,1'-bis-(diphenylphosphino)ferrocene; n-butyllithium; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; N,N,N,N,-tetramethylethylenediamine; hydrogen bromide; dihydrogen peroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 7: Grignard reaction;
DOI:10.1016/j.bmcl.2004.03.067