3-(3-(1-(2-(benzyloxy)phenyl)cyclobutylamino)-5-bromo-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide

Base Information

Chemical Name:3-(3-(1-(2-(benzyloxy)phenyl)cyclobutylamino)-5-bromo-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide
CAS No.:1095006-18-0
Molecular Formula:C₃₂H₃₁BrN₄O₃
Molecular Weight:599.527
Hs Code.:

Synonyms:3-(3-(1-(2-(benzyloxy)phenyl)cyclobutylamino)-5-bromo-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide

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Chemical Property of 3-(3-(1-(2-(benzyloxy)phenyl)cyclobutylamino)-5-bromo-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide

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Technology Process of 3-(3-(1-(2-(benzyloxy)phenyl)cyclobutylamino)-5-bromo-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide

There total 10 articles about 3-(3-(1-(2-(benzyloxy)phenyl)cyclobutylamino)-5-bromo-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095006-17-9
methyl 3-(3-(1-(2-(benzyloxy)phenyl)cyclobutylamino)-5-bromo-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate

: 765-30-0
Cyclopropylamine

: 1095006-18-0
3-(3-(1-(2-(benzyloxy)phenyl)cyclobutylamino)-5-bromo-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide

Guidance literature:: methyl 3-(3-(1-(2-(benzyloxy)phenyl)cyclobutylamino)-5-bromo-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate; Cyclopropylamine; With isopropylmagnesium chloride; In tetrahydrofuran; at 20 ℃; for 1.16667h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 1095005-59-6
methyl 3-(3,5-dibromo-2-oxopyrazin-1(2H)-yl)-4-methylbenzoate

: 1095006-18-0
3-(3-(1-(2-(benzyloxy)phenyl)cyclobutylamino)-5-bromo-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 16 h / 100 °C

2: isopropylmagnesium chloride / tetrahydrofuran / 1.17 h / 20 °C

With isopropylmagnesium chloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 1095006-13-5
1-(2-methoxyphenyl)cyclobutanecarboxamide

: 1095006-18-0
3-(3-(1-(2-(benzyloxy)phenyl)cyclobutylamino)-5-bromo-2-oxopyrazin-1(2H)-yl)-N-cyclopropyl-4-methylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: boron tribromide / dichloromethane / 3 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h

3.1: bis-[(trifluoroacetoxy)iodo]benzene / water; acetonitrile / 16 h / 20 °C

3.2: pH 13

4.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 16 h / 100 °C

5.1: isopropylmagnesium chloride / tetrahydrofuran / 1.17 h / 20 °C

With isopropylmagnesium chloride; boron tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;