1-[4-(2-methoxy-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutanamine

Base Information

Chemical Name:1-[4-(2-methoxy-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutanamine
CAS No.:1374261-31-0
Molecular Formula:C₂₅H₂₃N₅O
Molecular Weight:409.491
Hs Code.:

Synonyms:1-[4-(2-methoxy-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutanamine

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Chemical Property of 1-[4-(2-methoxy-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutanamine

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Technology Process of 1-[4-(2-methoxy-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutanamine

There total 7 articles about 1-[4-(2-methoxy-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 1374260-87-3
tert-butyl {1-[4-(2-bromo-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate

: 124-41-4
sodium methylate

: 1374261-31-0
1-[4-(2-methoxy-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutanamine

Guidance literature:: With copper(l) iodide; at 100 ℃; for 24h;

Reference yield:

: 885-70-1
5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one

: 1374261-31-0
1-[4-(2-methoxy-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutanamine

Guidance literature:: Multi-step reaction with 7 steps

1: Lawessons reagent; pyridine / 18 h / 100 °C

2: 1 h / 95 °C

3: acetic acid / 13 h / 105 °C

4: N-Bromosuccinimide / tetrahydrofuran / 2 h / 0 - 20 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 15 h / Reflux

6: pyridinium perbromide hydrobromide / tetrahydrofuran / -78 - 20 °C

7: copper(l) iodide / 24 h / 100 °C

With Lawessons reagent; pyridine; N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; pyridinium perbromide hydrobromide; sodium hydrogencarbonate; acetic acid; In tetrahydrofuran; ethanol; water; toluene;

Reference yield:

: 1374260-83-9
3-bromo-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepine

: 1374261-31-0
1-[4-(2-methoxy-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutanamine

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydrogencarbonate / ethanol; water; toluene / 15 h / Reflux

2: pyridinium perbromide hydrobromide / tetrahydrofuran / -78 - 20 °C

3: copper(l) iodide / 24 h / 100 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; pyridinium perbromide hydrobromide; sodium hydrogencarbonate; In tetrahydrofuran; ethanol; water; toluene;