N-(4-methoxyphenyl)methyl-N²-(t-butoxycarbonyl)-L-glutamine 1-t-butyl ester

Base Information

• Chemical Name: N-(4-methoxyphenyl)methyl-N²-(t-butoxycarbonyl)-L-glutamine 1-t-butyl ester
• CAS No.: 235438-56-9
• Molecular Formula: C₂₂H₃₄N₂O₆
• Molecular Weight: 422.522
• Mol file: 235438-56-9.mol

Synonyms:N-(4-methoxyphenyl)methyl-N²-(t-butoxycarbonyl)-L-glutamine 1-t-butyl ester

Chemical Property of N-(4-methoxyphenyl)methyl-N²-(t-butoxycarbonyl)-L-glutamine 1-t-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-methoxyphenyl)methyl-N²-(t-butoxycarbonyl)-L-glutamine 1-t-butyl ester

There total 1 articles about N-(4-methoxyphenyl)methyl-N²-(t-butoxycarbonyl)-L-glutamine 1-t-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

N-tert-butoxycarbonyl glutamic acid tert-butyl ester (24277-39-2) + 4-methoxy-benzylamine (2393-23-9) → N-(4-methoxyphenyl)methyl-N2-(t-butoxycarbonyl)-L-glutamine 1-t-butyl ester (235438-56-9)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1016/S0031-9422(99)00055-2

Reference yield:

N-(4-methoxyphenyl)methyl-N2-(t-butoxycarbonyl)-L-glutamine 1-t-butyl ester (235438-56-9) → N5-(4-methoxyphenyl)methyl-L-glutamine

Guidance literature:

Multi-step reaction with 2 steps

1: TFA / 1 h / Ambient temperature

2: 80 mg / aq. NaOH

With sodium hydroxide; trifluoroacetic acid;

DOI:10.1016/S0031-9422(99)00055-2

upstream raw materials:

N-tert-butoxycarbonyl glutamic acid tert-butyl ester

4-methoxy-benzylamine