N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-N'-phenylmalonamide

Base Information

• Chemical Name: N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-N'-phenylmalonamide
• CAS No.: 1322643-95-7
• Molecular Formula: C₁₈H₁₇N₃O₂S
• Molecular Weight: 339.418

Synonyms:N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-N'-phenylmalonamide

Chemical Property of N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-N'-phenylmalonamide

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Technology Process of N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-N'-phenylmalonamide

There total 1 articles about N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-N'-phenylmalonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

aniline (62-53-3) + N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)malonamic acid ethyl ester (348621-54-5) → N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-N'-phenylmalonamide (1322643-95-7)

Guidance literature:

In N,N-dimethyl-formamide; for 5h; Reflux;

DOI:10.3390/molecules16086271

Reference yield: 80.0%

N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-N'-phenylmalonamide (1322643-95-7) + benzaldehyde (100-52-7) → 2-benzylidene-N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-N'-phenylmalonamide (1322643-97-9)

Guidance literature:

With piperidine; In 1,4-dioxane; for 5h; Reflux;

DOI:10.3390/molecules16086271

Reference yield: 70.0%

N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-N'-phenylmalonamide (1322643-95-7) + malononitrile (109-77-3) → 4,6-diamino-1-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid phenylamide (1322644-08-5)

Guidance literature:

With triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide; for 5h; Reflux;

DOI:10.3390/molecules16086271

upstream raw materials:

aniline

N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)malonamic acid ethyl ester

Downstream raw materials:

5-ethoxycarbonyl-2,4-bis-phenylaminothiophene-3-carboxylic acid (3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amide

5-benzoyl-2,4-bis-phenylaminothiophene-3-carboxylic acid (3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amide

N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-2-(4-methyl-3-phenyl-3H-thiazol-2-ylidene)-N'-phenylmalonamide

2-[6-amino-3-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-4-imino-3,4-dihydro[1,3]oxazin-2-ylidene]-N-phenyl-2-phenylazoaceamide

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