4'-methyl-2',6'-di-tert-butylphenyl (2RS,3SR)-2-(benzyloxy)-3-hydroxy-2-methylpentanoate

Base Information

Chemical Name:4'-methyl-2',6'-di-tert-butylphenyl (2RS,3SR)-2-(benzyloxy)-3-hydroxy-2-methylpentanoate
CAS No.:92935-66-5
Molecular Formula:C₂₈H₄₀O₄
Molecular Weight:440.623
Hs Code.:

Synonyms:4'-methyl-2',6'-di-tert-butylphenyl (2RS,3SR)-2-(benzyloxy)-3-hydroxy-2-methylpentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4'-methyl-2',6'-di-tert-butylphenyl (2RS,3SR)-2-(benzyloxy)-3-hydroxy-2-methylpentanoate

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Technology Process of 4'-methyl-2',6'-di-tert-butylphenyl (2RS,3SR)-2-(benzyloxy)-3-hydroxy-2-methylpentanoate

There total 7 articles about 4'-methyl-2',6'-di-tert-butylphenyl (2RS,3SR)-2-(benzyloxy)-3-hydroxy-2-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-38-6
propionaldehyde

: 78957-59-2
2',6'-di-tert-butyl-4'-methylphenyl (RS)-2-(benzyloxy)propanoate

: 92935-64-3
4'-methyl-2',6'-di-tert-butylphenyl (2RS,3SR)-2-(benzyloxy)-3-hydroxy-2-methylpentanoate

: 92935-66-5
4'-methyl-2',6'-di-tert-butylphenyl (2RS,3SR)-2-(benzyloxy)-3-hydroxy-2-methylpentanoate

Guidance literature:: With lithium diisopropyl amide; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) THF, -78 deg C, 45 min, 2.) -78 deg C;
DOI:10.1021/ja00406a064

Reference yield:

: 56972-68-0
2-benzyloxy-propionyl chloride

: 92935-66-5
4'-methyl-2',6'-di-tert-butylphenyl (2RS,3SR)-2-(benzyloxy)-3-hydroxy-2-methylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / 1.5 M n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 3 h; 2.) r.t., overnight

2: LDA / tetrahydrofuran / 0.33 h / -78 °C

With n-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1021/ja00338a027

Reference yield:

: 128-37-0
2,6-di-tert-butyl-4-methyl-phenol

: 92935-66-5
4'-methyl-2',6'-di-tert-butylphenyl (2RS,3SR)-2-(benzyloxy)-3-hydroxy-2-methylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / 1.5 M n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 3 h; 2.) r.t., overnight

2: LDA / tetrahydrofuran / 0.33 h / -78 °C

With n-butyllithium; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1021/ja00338a027