56972-68-0Relevant articles and documents
Mutual kinetic resolution of 3-methyl-3,4-dihydro-2H-1,4-benzoxazines and 2-alkoxyacyl chlorides
Vakarov, Sergey A.,Gruzdev, Dmitry А.,Sadretdinova, Liliya Sh.,Kodess, Mikhail I.,Tumashov, Andrey A.,Gorbunov, Evgeny B.,Levit, Galina L.,Krasnov, Victor P.
, p. 437 - 446 (2018/06/14)
[Figure not available: see fulltext.] Stereoselective acylation of racemic 3-methyl-3,4-dihydro-2Н-1,4-benzoxazine and its 7,8-difluoro-substituted analog with racemic 2-alkoxyacyl chlorides was stidied. The reactions of 3-methyl-3,4-dihydro-2H-1,4-benzoxazines with 2-methoxyisopentanoyl chloride were found to be more selective (selectivity factor s 31–32) compared to the acylation with other studied propanoyl chlorides (s 18–21). This fact was probably caused by the significant steric hindrance due to the isopropyl substituent in acyl chloride compared to the methyl group in reagents derived from propanoic acid.
Iterative Assembly of Macrocyclic Lactones using Successive Ring Expansion Reactions
Stephens, Thomas C.,Lawer, Aggie,French, Thomas,Unsworth, William P.
supporting information, p. 13947 - 13953 (2018/09/14)
Macrocyclic lactones can be prepared from lactams and hydroxyacid derivatives via an efficient 3- or 4-atom iterative ring expansion protocol. The products can also be expanded using amino acid-based linear fragments, meaning that macrocycles with precise
AZACYCLIC COMPOUNDS AS INHIBITORS OF SENSORY NEURONE SPECIFIC CHANNELS
-
Page 63, (2010/02/10)
Compounds of the formula (I), and pharmaceutically acceptable salts thereof, are found to be antagonists of SNS sodium channels. They are therefore useful as analgesic and neuroprotective agents wherein: X is -N- or -CH-; n is from 0 to 3.
Process for the preparation of 2-hydroxyalkyl halophenones
-
, (2008/06/13)
A process is provided for the preparation of compounds of Formula (1): wherein X1and X2are each independently H, Cl or F, provided that at least one of X1and X2is Cl or F; one of R1and R2is H and the other is OH; and R5is an unsubstituted alkyl, preferably a C1-6alkyl, group. The process comprises condensing a 2-chloroalkanoic acid with an optionally substituted benzyl alcohol to form a 2-(optionally substituted benzyloxy) alkanoic acid, converting the condensation product to the corresponding acid chloride and then either reacting the acid chloride with a compound of the Formula (2) in the presence of a source of copper (I) to give a compound of Formula (3) wherein one of R3and R4is H and the other is optionally substituted benzyloxy; or reacting the acid chloride with a compound of Formula (4): A—NH—B wherein A and B independently represent substituted alkyl, alkoxy, aryl or oxyaryl groups, or are linked to form a heterocyclic ring to form an amide, and then reacting the amide with a compound of Formula (2) to give a compound of Formula (3). The optionally substituted benzyl group from the compound of Formula (3) can removed by hydrogenation.
THE STUDIES OF METAL ION CATALYZED CARBON-HYDROGEN INSERTION OF α-ALKOXY-α'-DIAZOKETONES DERIVED FROM MANDELIC AND LACTIC ACIDS
Hon, Yung-Son,Chang, Rong-Chi,Chau, Tay-Yuan
, p. 1745 - 1750 (2007/10/02)
The cupric acetylacetonate is the best catalyst to induce the carbon-hydrogen inserted reaction for the α-alkoxy-α'-diazoketones derivatives (5 and 6).The side reactions such as aromatic carbon-hydrogen insertion and rearrangement could be prevented.
Rhodium Acetate Catalyzes the Addition of Carbenoids α- to Ether Oxygens
Adams, Julian,Poupart, Marc-Andre,Grenier, Louis,Schaller, Chris,Ouimet, Nathalie,Frenette, Richard
, p. 1749 - 1752 (2007/10/02)
Diazo-carbonyl compounds, when catalyzed by rhodium acetate, insert preferentially adjacent to ether oxygens.This phenomenon was exploited to develop a synthesis of 3(2H)-furanones.
