2,4,6-trimethylphenyl trifluoromethanesulfonate

Base Information

• Chemical Name: 2,4,6-trimethylphenyl trifluoromethanesulfonate
• CAS No.: 125261-32-7
• Molecular Formula: C₁₀H₁₁F₃O₃S
• Molecular Weight: 268.257
• Mol file: 125261-32-7.mol

Synonyms:2,4,6-trimethylphenyl trifluoromethanesulfonate

Chemical Property of 2,4,6-trimethylphenyl trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4,6-trimethylphenyl trifluoromethanesulfonate

There total 3 articles about 2,4,6-trimethylphenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

trifluoromethylsulfonic anhydride (358-23-6) + Mesitol (527-60-6) → 2,4,6-trimethylphenyl trifluoromethanesulfonate (125261-32-7)

Guidance literature:

With triethylamine; In dichloromethane; at -78 - 20 ℃; for 14h; Inert atmosphere;

DOI:10.1039/c7ob02531a

Reference yield: 71.0%

dihydroxy-methyl-borane (13061-96-6) + C9H8ClF3O3S → 2,4,6-trimethylphenyl trifluoromethanesulfonate (125261-32-7)

Guidance literature:

With potassium fluoride; palladium diacetate; C₂₁H₃₂NP; In tert-butyl alcohol; at 110 ℃; for 2h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/acscatal.1c02146

Reference yield: 71.0%

→ 2,4,6-trimethylphenyl trifluoromethanesulfonate (125261-32-7)

Guidance literature:

With palladium diacetate; 2-cyclohexyl-3-(diisopropylphosphino)-1-methyl-1H-indole; In tetrahydrofuran; tert-butyl alcohol; at 110 ℃; for 2h; chemoselective reaction; Schlenk technique; Inert atmosphere;

upstream raw materials:

trifluoromethylsulfonic anhydride

Mesitol

dihydroxy-methyl-borane

Downstream raw materials:

(E)-4-mesityl-3-buten-2-one

4-mesitylbutan-2-one

1-fluoro-2,4,6-trimethylbenzene

2,3,5,6-tetrafluoro-4-mesitylpyridine