2,4,6-TRIMETHYLFLUOROBENZENE

Base Information

• Chemical Name: 2,4,6-TRIMETHYLFLUOROBENZENE
• CAS No.: 392-69-8
• Molecular Formula: C9H11 F
• Molecular Weight: 138.185
• Hs Code.: 2903999090
• Mol file: 392-69-8.mol

Synonyms:Mesitylene,2-fluoro- (6CI,7CI,8CI); 1-Fluoro-2,4,6-trimethylbenzene;2,4,6-Trimethyl-1-fluorobenzene; 2,4,6-Trimethylfluorobenzene;2-Fluoromesitylene; Mesityl fluoride; NSC 10359

Chemical Property of 2,4,6-TRIMETHYLFLUOROBENZENE

Chemical Property:

• Appearance/Colour: clear light yellow liquid
• Vapor Pressure: 2.02mmHg at 25°C
• Melting Point: -36.7℃
• Refractive Index: 1.483-1.485
• Boiling Point: 211.3°Cat760mmHg
• Flash Point: 81.6°C
• PSA: 0.00000
• Density: 1.178g/cm³
• LogP: 2.75090
• Storage Temp.: 2-8°C
• Water Solubility.: Soluble in water.

Purity/Quality:

97% ^*data from raw suppliers

2,4,6-Trimethylfluorobenzene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi,F
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• General Description: 2,4,6-Trimethylfluorobenzene (also known as 2-fluoromesitylene or mesityl fluoride) is a fluorinated aromatic compound derived from mesitylene, where one hydrogen is replaced by fluorine. It can be formed via selective reductive elimination from a platinum(IV) complex or through dediazoniation reactions of 2,4,6-trimethylbenzenediazonium salts, yielding products such as aryl fluorides. Its synthesis and reactivity are influenced by reaction conditions and intermediates, as demonstrated in studies involving metal complexes and diazonium chemistry.

Technology Process of 2,4,6-TRIMETHYLFLUOROBENZENE

There total 55 articles about 2,4,6-TRIMETHYLFLUOROBENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2,4,6-trimethylphenyl trifluoromethanesulfonate (125261-32-7) → 1-fluoro-2,4,6-trimethylbenzene (392-69-8)

Guidance literature:

With cesium fluoride; bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; t-BuBrettPhos; In toluene; at 130 ℃; Sealed tube;

Reference yield: 85.0%

(phenyl)(2,4,6-trimethylphenyl)iodonium tetrafluoroborate → fluorobenzene (462-06-6) + 1-fluoro-2,4,6-trimethylbenzene (392-69-8)

Guidance literature:

With potassium fluoride; 18-crown-6 ether; copper(II) methanesulfonate; In N,N-dimethyl-formamide; at 60 ℃; for 18h; Reagent/catalyst; Time; Solvent;

DOI:10.1021/ol4025716

Reference yield: 82.0%

2,4,6-trimethylphenyl bromide (576-83-0) → 1-fluoro-2,4,6-trimethylbenzene (392-69-8) + 1,3,5-trimethyl-benzene (108-67-8)

Guidance literature:

2,4,6-trimethylphenyl bromide; With n-butyllithium; In tetrahydrofuran; hexane; at 0 ℃; Flow reactor;

With N-fluorobis(benzenesulfon)imide; In tetrahydrofuran; hexane; at 0 ℃; Reagent/catalyst; Flow reactor;

DOI:10.1002/asia.201201191

upstream raw materials:

2,4,6-trimethylaniline

2,2,2-trifluoroethanol

potassium thioacyanate

[D₃]acetonitrile

Downstream raw materials:

Mesitol

2,4,6-trimethylanisole

2-(2,4,6-trimethylphenyl)malonic acid diethyl ester

tri-n-butyl(mesityl)stannane