(2-iodo-5-nitro-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

Base Information

• Chemical Name: (2-iodo-5-nitro-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester
• CAS No.: 250684-77-6
• Molecular Formula: C₂₂H₁₇IN₂O₄
• Molecular Weight: 500.292
• Mol file: 250684-77-6.mol

Synonyms:(2-iodo-5-nitro-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property of (2-iodo-5-nitro-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (2-iodo-5-nitro-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

There total 1 articles about (2-iodo-5-nitro-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + 2-iodo-5-nitro-benzylamine (250684-76-5) → (2-iodo-5-nitro-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (250684-77-6)

Guidance literature:

With N,N-diethyl-N-isopropylamine; In tetrahydrofuran;

DOI:10.1016/S0040-4039(99)01400-8

Reference yield: 95.0%

(2-iodo-5-nitro-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (250684-77-6) → (5-amino-2-iodo-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:

With ammonium chloride; zinc; In 2-methoxy-ethanol;

DOI:10.1016/S0040-4039(99)01400-8

Reference yield:

(2-iodo-5-nitro-benzyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (250684-77-6) → 3-{3-[(9H-fluoren-9-ylmethoxycarbonylamino)-methyl]-4-iodo-phenylazo}-benzoic acid tert-butyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / Zn; NH₄Cl / 2-methoxy-ethanol

2: 78 percent / acetic acid / 20 °C

With ammonium chloride; zinc; In 2-methoxy-ethanol; acetic acid; 1: Reduction / 2: Condensation;

DOI:10.1016/S0040-4039(99)01400-8

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

2-iodo-5-nitro-benzylamine