(S)-N-(3-(4-(5-chloro-7-((1,1,1-trifluoropropan-2-yl)amino)-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3,5-difluorophenoxy)propyl)acetamide

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Chemical Name:(S)-N-(3-(4-(5-chloro-7-((1,1,1-trifluoropropan-2-yl)amino)-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3,5-difluorophenoxy)propyl)acetamide
CAS No.:1584642-04-5
Molecular Formula:C₁₉H₁₈ClF₅N₆O₂
Molecular Weight:492.836
Hs Code.:

Synonyms:(S)-N-(3-(4-(5-chloro-7-((1,1,1-trifluoropropan-2-yl)amino)-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3,5-difluorophenoxy)propyl)acetamide

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Chemical Property of (S)-N-(3-(4-(5-chloro-7-((1,1,1-trifluoropropan-2-yl)amino)-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3,5-difluorophenoxy)propyl)acetamide

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Technology Process of (S)-N-(3-(4-(5-chloro-7-((1,1,1-trifluoropropan-2-yl)amino)-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3,5-difluorophenoxy)propyl)acetamide

There total 6 articles about (S)-N-(3-(4-(5-chloro-7-((1,1,1-trifluoropropan-2-yl)amino)-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3,5-difluorophenoxy)propyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: (S)-6-(4-(3-aminopropoxy)-2,6-difluorophenyl)-5-chloro-N-(1,1,1-trifluoropropan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine

: 108-24-7
acetic anhydride

: 1584642-04-5
(S)-N-(3-(4-(5-chloro-7-((1,1,1-trifluoropropan-2-yl)amino)-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3,5-difluorophenoxy)propyl)acetamide

Guidance literature:: (S)-6-(4-(3-aminopropoxy)-2,6-difluorophenyl)-5-chloro-N-(1,1,1-trifluoropropan-2-yl)-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

acetic anhydride; In N,N-dimethyl-formamide; at 20 ℃; for 1h;
DOI:10.1021/jm5005623

Reference yield:

: 262609-07-4
diethyl (2,4,6-trifluoro-phenyl)-malonate

: 1584642-04-5
(S)-N-(3-(4-(5-chloro-7-((1,1,1-trifluoropropan-2-yl)amino)-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3,5-difluorophenoxy)propyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tributyl-amine / 2 h / 170 °C

2.1: sodium hydroxide / toluene

3.1: trichlorophosphate / 6 h / 130 °C

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 90 °C

5.1: sodium hydride / mineral oil; dimethyl sulfoxide; tetrahydrofuran / 1 h / 60 °C

5.2: 60 °C

6.1: triethylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

6.2: 1 h / 20 °C

With tributyl-amine; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; mineral oil;
DOI:10.1021/jm5005623

Reference yield:

: bis-sodium salt of 6-(2,4,6-trifluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidine-5,7-diol

: 1584642-04-5
(S)-N-(3-(4-(5-chloro-7-((1,1,1-trifluoropropan-2-yl)amino)-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-3,5-difluorophenoxy)propyl)acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: trichlorophosphate / 6 h / 130 °C

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 - 90 °C

3.1: sodium hydride / mineral oil; dimethyl sulfoxide; tetrahydrofuran / 1 h / 60 °C

3.2: 60 °C

4.1: triethylamine / N,N-dimethyl-formamide / 0.17 h / 20 °C

4.2: 1 h / 20 °C

With sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm5005623