1-acetylcyclohexyl pyrrolidine-1-carboxylate

Base Information

• Chemical Name: 1-acetylcyclohexyl pyrrolidine-1-carboxylate
• CAS No.: 1065469-94-4
• Molecular Formula: C₁₃H₂₁NO₃
• Molecular Weight: 239.315
• Mol file: 1065469-94-4.mol

Synonyms:1-acetylcyclohexyl pyrrolidine-1-carboxylate

Chemical Property of 1-acetylcyclohexyl pyrrolidine-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-acetylcyclohexyl pyrrolidine-1-carboxylate

There total 3 articles about 1-acetylcyclohexyl pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

pyrrolidine (123-75-1) + carbon dioxide (124-38-9,18923-20-1) + 1-Ethynylcyclohexan-1-ol (78-27-3) → 1-acetylcyclohexyl pyrrolidine-1-carboxylate (1065469-94-4)

Guidance literature:

With 1-methyl-2,3,4,6,7,8-hexahydro-1H-pyrimido[1,2-a]pyrimidine; at 100 ℃; for 24h; under 7500.75 Torr; Autoclave;

DOI:10.1002/adsc.201000607

Reference yield:

pyrrolidine (123-75-1) + 1-Ethynylcyclohexan-1-ol (78-27-3) → 1-acetylcyclohexyl pyrrolidine-1-carboxylate (1065469-94-4)

Guidance literature:

With carbon dioxide; In water; at 70 ℃; under 1500.15 Torr; Schlenk technique; Green chemistry;

DOI:10.1007/s10562-020-03313-w

Reference yield:

1-Ethynylcyclohexan-1-ol (78-27-3) → 1-acetylcyclohexyl pyrrolidine-1-carboxylate (1065469-94-4)

Guidance literature:

Multi-step reaction with 2 steps

1: silver carbonate; P(p-CH₃OC₆H₄)3 / chloroform / 25 °C / 15001.5 Torr

2: chloroform / 2 h

With P(p-CH₃OC₆H₄)3; silver carbonate; In chloroform;

DOI:10.1002/cjoc.201700572

upstream raw materials:

pyrrolidine

carbon dioxide

1-Ethynylcyclohexan-1-ol