methyl 2-benzyl-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate

Base Information

• Chemical Name: methyl 2-benzyl-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate
• CAS No.: 439944-52-2
• Molecular Formula: C₁₈H₂₃NO₅
• Molecular Weight: 333.384
• Mol file: 439944-52-2.mol

Synonyms:methyl 2-benzyl-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate

Chemical Property of methyl 2-benzyl-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-benzyl-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate

There total 3 articles about methyl 2-benzyl-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

sodium methylate (124-41-4) + benzyl bromide (100-39-0) + ethyl 3-<1-(methoxycarbonyl)-4-piperidyl>-3-oxopropanoate (167414-69-9) → methyl 2-benzyl-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate (439944-52-2)

Guidance literature:

In methanol; for 16h; Heating;

DOI:10.1021/jm020027o

Reference yield:

1-methoxycarbonyl-4-piperidinecarboxylic acid chloride (197585-43-6) → methyl 2-benzyl-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate (439944-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 65 percent / Et₃N; MgCl₂ / ethyl acetate / 20 °C

2: 60 percent / methanol / 16 h / Heating

With triethylamine; magnesium chloride; In methanol; ethyl acetate;

DOI:10.1021/jm020027o

Reference yield:

1-(methoxycarbonyl)piperidine-4-carboxylic acid (197585-42-5) → methyl 2-benzyl-3-(1-methoxycarbonyl-4-piperidyl)-3-oxopropionate (439944-52-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / SOCl₂ / dimethylformamide / 0.33 h / 85 °C

2: 65 percent / Et₃N; MgCl₂ / ethyl acetate / 20 °C

3: 60 percent / methanol / 16 h / Heating

With thionyl chloride; triethylamine; magnesium chloride; In methanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm020027o

upstream raw materials:

sodium methylate

benzyl bromide

ethyl 3-<1-(methoxycarbonyl)-4-piperidyl>-3-oxopropanoate

1-methoxycarbonyl-4-piperidinecarboxylic acid chloride

Downstream raw materials:

4-benzyl-5-(1-methoxycarbonyl-4-piperidyl)-3-isoxazolol