2-(1H-tetrazol-5-yl)-N-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluorobutoxy)-phenyl)butan-2-yl)acetamide

Base Information

Chemical Name:2-(1H-tetrazol-5-yl)-N-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluorobutoxy)-phenyl)butan-2-yl)acetamide
CAS No.:1441057-83-5
Molecular Formula:C₂₄H₂₃F₆N₅O₃
Molecular Weight:543.469
Hs Code.:

Synonyms:2-(1H-tetrazol-5-yl)-N-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluorobutoxy)-phenyl)butan-2-yl)acetamide

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Chemical Property of 2-(1H-tetrazol-5-yl)-N-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluorobutoxy)-phenyl)butan-2-yl)acetamide

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Technology Process of 2-(1H-tetrazol-5-yl)-N-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluorobutoxy)-phenyl)butan-2-yl)acetamide

There total 8 articles about 2-(1H-tetrazol-5-yl)-N-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluorobutoxy)-phenyl)butan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21743-75-9
ethyl 2-(1H-tetrazol-5-yl)acetate

: 1441057-81-3
3-amino-4,4,4-trifluoro-1-p-tolyl-3-(4-(4,4,4-trifluorobutoxy)phenyl)-butan-1-one

: 1441057-83-5
2-(1H-tetrazol-5-yl)-N-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluorobutoxy)-phenyl)butan-2-yl)acetamide

Guidance literature:: With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 280776-44-5
4-(4,4,4-trifluorobutoxy)benzaldehyde

: 1441057-83-5
2-(1H-tetrazol-5-yl)-N-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluorobutoxy)-phenyl)butan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: cesium fluoride / 1,2-dimethoxyethane / 16 h / 20 °C

2: Dess-Martin periodane / dichloromethane / 3.5 h / 0 - 20 °C

3: dimethyl sulfoxide / 160 °C / Microwave irradiation

4: ammonium hydroxide / dimethyl sulfoxide; water / 48 h / Sealed tube

5: dicyclohexyl-carbodiimide / tetrahydrofuran / 0 - 20 °C

With ammonium hydroxide; Dess-Martin periodane; dicyclohexyl-carbodiimide; cesium fluoride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1441057-83-5
2-(1H-tetrazol-5-yl)-N-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluorobutoxy)-phenyl)butan-2-yl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere

2: cesium fluoride / 1,2-dimethoxyethane / 16 h / 20 °C

3: Dess-Martin periodane / dichloromethane / 3.5 h / 0 - 20 °C

4: dimethyl sulfoxide / 160 °C / Microwave irradiation

5: ammonium hydroxide / dimethyl sulfoxide; water / 48 h / Sealed tube

6: dicyclohexyl-carbodiimide / tetrahydrofuran / 0 - 20 °C

With ammonium hydroxide; di-isopropyl azodicarboxylate; Dess-Martin periodane; dicyclohexyl-carbodiimide; triphenylphosphine; cesium fluoride; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide;