methyl 2-(4-(2-aminophenyl)-2-(methoxycarbonylamino)pyrrolo[1,2-f][1,2,4]triazin-5-yl)-2-(4-hydroxyphenyl)acetate

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Chemical Name:methyl 2-(4-(2-aminophenyl)-2-(methoxycarbonylamino)pyrrolo[1,2-f][1,2,4]triazin-5-yl)-2-(4-hydroxyphenyl)acetate
CAS No.:1426668-49-6
Molecular Formula:C₂₃H₂₁N₅O₅
Molecular Weight:447.45
Hs Code.:

Synonyms:methyl 2-(4-(2-aminophenyl)-2-(methoxycarbonylamino)pyrrolo[1,2-f][1,2,4]triazin-5-yl)-2-(4-hydroxyphenyl)acetate

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Chemical Property of methyl 2-(4-(2-aminophenyl)-2-(methoxycarbonylamino)pyrrolo[1,2-f][1,2,4]triazin-5-yl)-2-(4-hydroxyphenyl)acetate

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Technology Process of methyl 2-(4-(2-aminophenyl)-2-(methoxycarbonylamino)pyrrolo[1,2-f][1,2,4]triazin-5-yl)-2-(4-hydroxyphenyl)acetate

There total 10 articles about methyl 2-(4-(2-aminophenyl)-2-(methoxycarbonylamino)pyrrolo[1,2-f][1,2,4]triazin-5-yl)-2-(4-hydroxyphenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1426668-46-3
methyl 3-(4-hydroxyphenyl)-10-((methoxycarbonyl)amino)-3,4-dihydro-4,9,11,11a-tetraazadibenzo[cd,f]azulene-3-carboxylate

: 1426668-49-6
methyl 2-(4-(2-aminophenyl)-2-(methoxycarbonylamino)pyrrolo[1,2-f][1,2,4]triazin-5-yl)-2-(4-hydroxyphenyl)acetate

Guidance literature:: With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; water; for 82h; under 2844.39 Torr;

Reference yield:

: 1426663-88-8
methyl (4-(2-aminophenyl)pyrrolo[2,1-f][1,2,4]triazin-2-yl)carbamate

: 1426668-49-6
methyl 2-(4-(2-aminophenyl)-2-(methoxycarbonylamino)pyrrolo[1,2-f][1,2,4]triazin-5-yl)-2-(4-hydroxyphenyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane; methanol / 48 h / 100 °C / Sealed tube

2: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 82 h / 2844.39 Torr

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In 1,4-dioxane; methanol; water;

Reference yield:

: 628733-99-3
ethyl 1-amino-1H-pyrrole-2-carboxylate

: 1426668-49-6
methyl 2-(4-(2-aminophenyl)-2-(methoxycarbonylamino)pyrrolo[1,2-f][1,2,4]triazin-5-yl)-2-(4-hydroxyphenyl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid / methanol / 16 h / 20 °C

2: sodium methylate / methanol / 16 h / 20 °C

3: N-benzyl-N,N,N-triethylammonium chloride; N,N-diethylaniline; trichlorophosphate / acetonitrile / 15 h / 80 °C

4: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / water; N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

5: hydrogenchloride / 1,4-dioxane; methanol / 48 h / 100 °C / Sealed tube

6: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 82 h / 2844.39 Torr

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; sodium methylate; sodium carbonate; acetic acid; N,N-diethylaniline; trichlorophosphate; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; acetonitrile;