ethyl (4-(4-amino-3-fluorophenoxy)-2-aminopyridin-3-yl)(methyl)carbamate

Base Information

Chemical Name:ethyl (4-(4-amino-3-fluorophenoxy)-2-aminopyridin-3-yl)(methyl)carbamate
CAS No.:1160825-93-3
Molecular Formula:C₁₅H₁₇FN₄O₃
Molecular Weight:320.323
Hs Code.:

Synonyms:ethyl (4-(4-amino-3-fluorophenoxy)-2-aminopyridin-3-yl)(methyl)carbamate

Suppliers and Price of ethyl (4-(4-amino-3-fluorophenoxy)-2-aminopyridin-3-yl)(methyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl (4-(4-amino-3-fluorophenoxy)-2-aminopyridin-3-yl)(methyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl (4-(4-amino-3-fluorophenoxy)-2-aminopyridin-3-yl)(methyl)carbamate

There total 6 articles about ethyl (4-(4-amino-3-fluorophenoxy)-2-aminopyridin-3-yl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1160825-91-1
ethyl 4-(4-amino-3-fluorophenoxy)-2-aminopyridin-3-yl-carbamate

: 74-88-4
methyl iodide

: 1160825-93-3
ethyl (4-(4-amino-3-fluorophenoxy)-2-aminopyridin-3-yl)(methyl)carbamate

Guidance literature:: ethyl 4-(4-amino-3-fluorophenoxy)-2-aminopyridin-3-yl-carbamate; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.666667h;

methyl iodide; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 0.666667h;
DOI:10.1021/jm900242c

Reference yield:

: 1163720-60-2
4-(4-N-(tert-butoxycarbonyl)amino-3-fluorophenoxy)-3-nitro-2-aminopyridine

: 1160825-93-3
ethyl (4-(4-amino-3-fluorophenoxy)-2-aminopyridin-3-yl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / 10% palladium on activated charcoal / ethyl acetate; ethanol / 5 h

2.1: pyridine / tetrahydrofuran / 24.5 h / 0 - 20 °C

3.1: trifluoroacetic acid / water / 2 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.67 h / 0 °C

4.2: 18 h / 0 - 20 °C

With pyridine; hydrogen; sodium hydride; trifluoroacetic acid; 10% palladium on activated charcoal; In tetrahydrofuran; ethanol; water; ethyl acetate; mineral oil;

Reference yield:

: 911297-02-4
N-(2-fluoro-4-hydroxyphenyl)carbamic acid tert-butyl ester

: 1160825-93-3
ethyl (4-(4-amino-3-fluorophenoxy)-2-aminopyridin-3-yl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.25 h / 20 °C / Inert atmosphere

1.2: 1 h / 110 °C

2.1: hydrogen / 10% palladium on activated charcoal / ethyl acetate; ethanol / 5 h

3.1: pyridine / tetrahydrofuran / 24.5 h / 0 - 20 °C

4.1: trifluoroacetic acid / water / 2 h / 20 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.67 h / 0 °C

5.2: 18 h / 0 - 20 °C

With pyridine; hydrogen; sodium hydride; trifluoroacetic acid; 10% palladium on activated charcoal; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; ethyl acetate; mineral oil;