tert-butyl 2-(2-hydroxy-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate

Base Information

Chemical Name:tert-butyl 2-(2-hydroxy-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate
CAS No.:1237519-59-3
Molecular Formula:C₂₉H₃₂N₂O₅
Molecular Weight:488.583
Hs Code.:

Synonyms:tert-butyl 2-(2-hydroxy-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate

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Chemical Property of tert-butyl 2-(2-hydroxy-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate

Chemical Property:

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Technology Process of tert-butyl 2-(2-hydroxy-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate

There total 4 articles about tert-butyl 2-(2-hydroxy-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1237519-58-2
tert-butyl 2-(2-(benzyloxy)-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate

: 1237519-59-3
tert-butyl 2-(2-hydroxy-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; at 20 ℃; for 1h;

Reference yield:

: 97231-91-9
4-(tert-butyldimethylsilyloxy)piperidine

: 1237519-59-3
tert-butyl 2-(2-hydroxy-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / palladium diacetate; XPhos / toluene / 4.5 h / Reflux; Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C

2.2: Cooling with ice

3.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 1 h / 20 °C

With tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; palladium 10% on activated carbon; palladium diacetate; XPhos; In tetrahydrofuran; methanol; ethyl acetate; toluene;

Reference yield:

: 1237519-57-1
tert-butyl 2-(2-(benzyloxy)-5-(4-(tert-butyldimethylsilyloxy)piperidin-1-yl)benzamido)-4-phenylbenzoate

: 1237519-59-3
tert-butyl 2-(2-hydroxy-5-(4-hydroxypiperidin-1-yl)benzamido)-4-phenylbenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 5 h / 20 °C

1.2: Cooling with ice

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; methanol / 1 h / 20 °C

With tetrabutyl ammonium fluoride; hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethyl acetate;