trans-N-(2-(4-acetamido-4-methylcyclohexyl)propan-2-yl)acetamide

Base Information

• Chemical Name: trans-N-(2-(4-acetamido-4-methylcyclohexyl)propan-2-yl)acetamide
• CAS No.: 127322-88-7
• Molecular Formula: C₁₄H₂₆N₂O₂
• Molecular Weight: 254.373
• Mol file: 127322-88-7.mol

Synonyms:trans-N-(2-(4-acetamido-4-methylcyclohexyl)propan-2-yl)acetamide

Chemical Property of trans-N-(2-(4-acetamido-4-methylcyclohexyl)propan-2-yl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of trans-N-(2-(4-acetamido-4-methylcyclohexyl)propan-2-yl)acetamide

There total 6 articles about trans-N-(2-(4-acetamido-4-methylcyclohexyl)propan-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

(-)-isopinocampheol (1196-00-5) + acetonitrile (75-05-8,26809-02-9) → trans-N-(2-(4-acetamido-4-methylcyclohexyl)propan-2-yl)acetamide (127322-88-7) + (R)-N-{1-methyl-1-[4-methylcyclohex-3-en-1-yl]ethyl}acetamide (144370-96-7) + (1S,5S,8R)-8-N-acetylamino-2,4,4,8-tetramethyl-3-azabicyclo<3.3.1>non-2-ene (93302-52-4)

Guidance literature:

With sulfuric acid; at 0 - 20 ℃; Yields of byproduct given;

Reference yield: 70.0%

(-)-isopinocampheol (1196-00-5) + acetonitrile (75-05-8,26809-02-9) → N-p-menth-1-en-8-ylacetamide (64374-24-9) + trans-N-(2-(4-acetamido-4-methylcyclohexyl)propan-2-yl)acetamide (127322-88-7) + (1S,5S,8R)-8-acetylamino-2,4,4,8-tetramethyl-3-azabicyclo<3.3.1>non-2-ene (93215-83-9)

Guidance literature:

With sulfuric acid; at 0 - 20 ℃;

Reference yield: 42.0%

terpin hydrate (80-53-5,89923-77-3) + acetonitrile (75-05-8,26809-02-9) → trans-N-(2-(4-acetamido-4-methylcyclohexyl)propan-2-yl)acetamide (127322-88-7) + cis-N-(2-(4-acetamido-4-methylcyclohexyl)propan-2-yl)acetamide (127322-84-3)

Guidance literature:

terpin hydrate; acetonitrile; With sulfuric acid; at 75 ℃; for 8h;

With water; sodium hydroxide; at 25 ℃; pH=7;

DOI:10.1021/acs.jafc.6b03977

upstream raw materials:

cis-1,8-terpine

acetonitrile

(-)-isopinocampheol

terpin hydrate

Downstream raw materials:

(E)-1,8-diamino-p-menthane