2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride

Base Information

Chemical Name:2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride
CAS No.:952675-18-2
Molecular Formula:C₁₈H₂₄ClFN₂O₂S
Molecular Weight:386.918
Hs Code.:

Synonyms:2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride

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Chemical Property of 2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride

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Technology Process of 2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride

There total 9 articles about 2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 881413-73-6
2-tert-Butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazol-5-amine

: 952675-18-2
2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride

Guidance literature:: 2-tert-Butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazol-5-amine; With hydrogenchloride; acetic acid; sodium nitrite; In water; at 0 ℃; for 1h;

With sulfur dioxide; acetic acid; copper dichloride; at -20 - 0 ℃; for 3h;

Reference yield:

: 809273-70-9
(4-oxo-cyclohexylmethyl)-carbamic acid tert-butyl ester

: 952675-18-2
2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: diethylamino-sulfur trifluoride / tetrahydrofuran / 5 h / 50 °C

2.1: hydrogenchloride; acetic acid / 2 h / 20 °C

3.1: triethylamine / ethanol / 48 h / 75 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 20 °C

5.1: dmap / dichloromethane / 1 h / 20 °C

5.2: 2.5 h / 150 °C

6.1: hydrogenchloride / ethanol / 1 h / 120 °C

7.1: hydrogenchloride; sodium nitrite; acetic acid / water / 1 h / 0 °C

7.2: 3 h / -20 - 0 °C

With hydrogenchloride; dmap; diethylamino-sulfur trifluoride; hydrogen; acetic acid; triethylamine; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 351-32-6
N-(4-fluoro-3-nitrophenyl)acetamide

: 952675-18-2
2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / ethanol / 48 h / 75 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 20 °C

3.1: dmap / dichloromethane / 1 h / 20 °C

3.2: 2.5 h / 150 °C

4.1: hydrogenchloride / ethanol / 1 h / 120 °C

5.1: hydrogenchloride; sodium nitrite; acetic acid / water / 1 h / 0 °C

5.2: 3 h / -20 - 0 °C

With hydrogenchloride; dmap; hydrogen; acetic acid; triethylamine; sodium nitrite; palladium 10% on activated carbon; In ethanol; dichloromethane; water; ethyl acetate;