1-({2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrrole-3-carbaldehyde

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Chemical Name:1-({2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrrole-3-carbaldehyde
CAS No.:952675-19-3
Molecular Formula:C₂₃H₂₈FN₃O₃S
Molecular Weight:445.558
Hs Code.:

Synonyms:1-({2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrrole-3-carbaldehyde

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Chemical Property of 1-({2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrrole-3-carbaldehyde

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Technology Process of 1-({2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrrole-3-carbaldehyde

There total 10 articles about 1-({2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrrole-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 952675-18-2
2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride

: 7126-39-8
pyrrole-3-carboxaldehyde

: 952675-19-3
1-({2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrrole-3-carbaldehyde

Guidance literature:: pyrrole-3-carboxaldehyde; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazole-5-sulfonyl chloride; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield:

: 351-32-6
N-(4-fluoro-3-nitrophenyl)acetamide

: 952675-19-3
1-({2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrrole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / ethanol / 48 h / 75 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 20 °C

3.1: dmap / dichloromethane / 1 h / 20 °C

3.2: 2.5 h / 150 °C

4.1: hydrogenchloride / ethanol / 1 h / 120 °C

5.1: hydrogenchloride; sodium nitrite; acetic acid / water / 1 h / 0 °C

5.2: 3 h / -20 - 0 °C

6.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C

6.2: 1 h / 0 °C

With hydrogenchloride; dmap; hydrogen; sodium hydride; acetic acid; triethylamine; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate;

Reference yield:

: 809273-70-9
(4-oxo-cyclohexylmethyl)-carbamic acid tert-butyl ester

: 952675-19-3
1-({2-tert-butyl-1-[(4-fluorocyclohexyl)methyl]-1H-benzimidazol-5-yl}sulfonyl)-1H-pyrrole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1.1: diethylamino-sulfur trifluoride / tetrahydrofuran / 5 h / 50 °C

2.1: hydrogenchloride; acetic acid / 2 h / 20 °C

3.1: triethylamine / ethanol / 48 h / 75 °C

4.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 48 h / 20 °C

5.1: dmap / dichloromethane / 1 h / 20 °C

5.2: 2.5 h / 150 °C

6.1: hydrogenchloride / ethanol / 1 h / 120 °C

7.1: hydrogenchloride; sodium nitrite; acetic acid / water / 1 h / 0 °C

7.2: 3 h / -20 - 0 °C

8.1: sodium hydride / tetrahydrofuran / 1 h / 0 - 20 °C

8.2: 1 h / 0 °C

With hydrogenchloride; dmap; diethylamino-sulfur trifluoride; hydrogen; sodium hydride; acetic acid; triethylamine; sodium nitrite; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate;