tert-butyl 5-(5-bromo-2-fluorophenyl)-6,6-difluoro-5-methyl-1,4-oxazepan-3-ylidenecarbamate

Base Information

Chemical Name:tert-butyl 5-(5-bromo-2-fluorophenyl)-6,6-difluoro-5-methyl-1,4-oxazepan-3-ylidenecarbamate
CAS No.:1262860-34-3
Molecular Formula:C₁₇H₂₀BrF₃N₂O₃
Molecular Weight:437.257
Hs Code.:

Synonyms:tert-butyl 5-(5-bromo-2-fluorophenyl)-6,6-difluoro-5-methyl-1,4-oxazepan-3-ylidenecarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 5-(5-bromo-2-fluorophenyl)-6,6-difluoro-5-methyl-1,4-oxazepan-3-ylidenecarbamate

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Technology Process of tert-butyl 5-(5-bromo-2-fluorophenyl)-6,6-difluoro-5-methyl-1,4-oxazepan-3-ylidenecarbamate

There total 22 articles about tert-butyl 5-(5-bromo-2-fluorophenyl)-6,6-difluoro-5-methyl-1,4-oxazepan-3-ylidenecarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1262860-33-2
5-(5-bromo-2-fluorophenyl)-6,6-difluoro-5-methyl-1,4-oxazepan-3-imine

: 1262860-34-3
tert-butyl 5-(5-bromo-2-fluorophenyl)-6,6-difluoro-5-methyl-1,4-oxazepan-3-ylidenecarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 ℃; for 2h;

Reference yield:

: 1262860-33-2
5-(5-bromo-2-fluorophenyl)-6,6-difluoro-5-methyl-1,4-oxazepan-3-imine

: 7087-68-5
N-ethyl-N,N-diisopropylamine

: 1262860-34-3
tert-butyl 5-(5-bromo-2-fluorophenyl)-6,6-difluoro-5-methyl-1,4-oxazepan-3-ylidenecarbamate

Guidance literature:: In tetrahydrofuran; hexane; ethyl acetate;

Reference yield:

: 1262860-26-3
N-(1-(5-bromo-2-fluorophenyl)-3-(tert-butyldimethylsilyloxy)-2,2-difluoropropylidene)-2-methylpropane-2-sulfinamide

: 1262860-34-3
tert-butyl 5-(5-bromo-2-fluorophenyl)-6,6-difluoro-5-methyl-1,4-oxazepan-3-ylidenecarbamate

Guidance literature:: Multi-step reaction with 7 steps

1: diethyl ether; hexane / 0.5 h / -35 - 0 °C

2: hydrogenchloride / methanol; hexane / 0.5 h / -22 °C

3: sodium carbonate / dichloromethane; water / 0.67 h / 0 °C / Cooling with ice

4: potassium tert-butylate / tert-butyl alcohol / 1.5 h / 20 °C / Reflux

5: Lawessons reagent / tetrahydrofuran; hexane / 16 h / Reflux

6: ammonia / methanol / 24 h / 20 °C / Sealed vessel

7: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 °C

With Lawessons reagent; hydrogenchloride; potassium tert-butylate; ammonia; sodium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water; tert-butyl alcohol;