3-Ethynyl-4-(4-fluoro-2-methylphenyl)-2-(1-methylethyl)-6-phenylpyridine

Base Information

Chemical Name:3-Ethynyl-4-(4-fluoro-2-methylphenyl)-2-(1-methylethyl)-6-phenylpyridine
CAS No.:137586-82-4
Molecular Formula:C₂₃H₂₀FN
Molecular Weight:329.417
Hs Code.:

Synonyms:3-Ethynyl-4-(4-fluoro-2-methylphenyl)-2-(1-methylethyl)-6-phenylpyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Ethynyl-4-(4-fluoro-2-methylphenyl)-2-(1-methylethyl)-6-phenylpyridine

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Technology Process of 3-Ethynyl-4-(4-fluoro-2-methylphenyl)-2-(1-methylethyl)-6-phenylpyridine

There total 9 articles about 3-Ethynyl-4-(4-fluoro-2-methylphenyl)-2-(1-methylethyl)-6-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 137586-82-4
3-Ethynyl-4-(4-fluoro-2-methylphenyl)-2-(1-methylethyl)-6-phenylpyridine

Guidance literature:

Reference yield:

: 135426-57-2
3-(2,2-Dibromoethenyl)-4-(4-fluoro-2-methylphenyl)-2-(1-methylethyl)-6-phenylpyridine

: 137586-82-4
3-Ethynyl-4-(4-fluoro-2-methylphenyl)-2-(1-methylethyl)-6-phenylpyridine

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;
DOI:10.1021/jm00113a019

Reference yield:

: 63082-45-1
4-fluoro-2-methylbenzaldehyde

: 137586-82-4
3-Ethynyl-4-(4-fluoro-2-methylphenyl)-2-(1-methylethyl)-6-phenylpyridine

Guidance literature:: Multi-step reaction with 7 steps

1: EtONa / ethanol / 15 h / Ambient temperature

2: EtONa / ethanol / 4.5 h / Ambient temperature

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

5: oxalyl chloride, DMSO / CH₂Cl₂; tetrahydrofuran / 0.25 h / -78 °C

6: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

7: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

With lithium aluminium tetrahydride; n-butyllithium; copper diacetate; oxalyl dichloride; ammonium acetate; sodium ethanolate; dimethyl sulfoxide; triphenylphosphine; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019