4-(4-Fluoro-2-methyl-phenyl)-3-((E)-2-iodo-vinyl)-2-isopropyl-6-phenyl-pyridine

Base Information

Chemical Name:4-(4-Fluoro-2-methyl-phenyl)-3-((E)-2-iodo-vinyl)-2-isopropyl-6-phenyl-pyridine
CAS No.:137587-00-9
Molecular Formula:C₂₃H₂₁FIN
Molecular Weight:457.329
Hs Code.:

Synonyms:4-(4-Fluoro-2-methyl-phenyl)-3-((E)-2-iodo-vinyl)-2-isopropyl-6-phenyl-pyridine

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Chemical Property of 4-(4-Fluoro-2-methyl-phenyl)-3-((E)-2-iodo-vinyl)-2-isopropyl-6-phenyl-pyridine

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Technology Process of 4-(4-Fluoro-2-methyl-phenyl)-3-((E)-2-iodo-vinyl)-2-isopropyl-6-phenyl-pyridine

There total 9 articles about 4-(4-Fluoro-2-methyl-phenyl)-3-((E)-2-iodo-vinyl)-2-isopropyl-6-phenyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63082-45-1
4-fluoro-2-methylbenzaldehyde

: 137587-00-9
4-(4-Fluoro-2-methyl-phenyl)-3-((E)-2-iodo-vinyl)-2-isopropyl-6-phenyl-pyridine

Guidance literature:: Multi-step reaction with 8 steps

1: EtONa / ethanol / 15 h / Ambient temperature

2: EtONa / ethanol / 4.5 h / Ambient temperature

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

5: oxalyl chloride, DMSO / CH₂Cl₂; tetrahydrofuran / 0.25 h / -78 °C

6: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

7: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

8: 1.) AIBN, tri-n-butyltin hydride, 2.) I₂ / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et₂O, RT, 45 min

With lithium aluminium tetrahydride; n-butyllithium; copper diacetate; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); ammonium acetate; iodine; tri-n-butyl-tin hydride; sodium ethanolate; dimethyl sulfoxide; triphenylphosphine; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019

Reference yield:

: 137586-78-8
3-(4-Fluoro-2-methylphenyl)-1-phenyl-2-propen-1-one

: 137587-00-9
4-(4-Fluoro-2-methyl-phenyl)-3-((E)-2-iodo-vinyl)-2-isopropyl-6-phenyl-pyridine

Guidance literature:: Multi-step reaction with 7 steps

1: EtONa / ethanol / 4.5 h / Ambient temperature

2: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

3: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

4: oxalyl chloride, DMSO / CH₂Cl₂; tetrahydrofuran / 0.25 h / -78 °C

5: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

6: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

7: 1.) AIBN, tri-n-butyltin hydride, 2.) I₂ / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et₂O, RT, 45 min

With lithium aluminium tetrahydride; n-butyllithium; copper diacetate; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); ammonium acetate; iodine; tri-n-butyl-tin hydride; sodium ethanolate; dimethyl sulfoxide; triphenylphosphine; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019

Reference yield:

: 137586-81-3
4-(4-Fluoro-2-methylphenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxaldehyde

: 137587-00-9
4-(4-Fluoro-2-methyl-phenyl)-3-((E)-2-iodo-vinyl)-2-isopropyl-6-phenyl-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

2: n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

3: 1.) AIBN, tri-n-butyltin hydride, 2.) I₂ / 1.) 120 deg C - 140 deg C, 3 h, 2.) Et₂O, RT, 45 min

With n-butyllithium; 2,2'-azobis(isobutyronitrile); iodine; tri-n-butyl-tin hydride; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jm00113a019