Technology Process of ethyl (S)-4-benzyl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylate
There total 12 articles about ethyl (S)-4-benzyl-9-(benzyloxy)-2-(2-methoxyethyl)-1,8-dioxo-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine-7-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; toluene;
at 20 ℃;
for 0.55h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.47 h / -78 °C
1.2: 0.17 h / 20 °C
2.1: sodium periodate; sulfuric acid / ruthenium trichloride / acetonitrile; water / 0.25 h / 20 °C / Inert atmosphere
3.1: aminosulfonic acid; sodium chlorite; sulfuric acid / acetonitrile; water / 0.17 h / 20 °C
4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1.5 h / 20 °C
4.2: 1.05 h / 0 °C
5.1: xylene / 0.5 h / 120 °C
6.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 0.55 h / 20 °C
With
sodium chlorite; sodium periodate; sulfuric acid; aminosulfonic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate;
ruthenium trichloride;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; acetonitrile; xylene;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: sodium tert-pentoxide / 1,3-dimethyl-2-imidazolidinone / 2 h / 20 - 40 °C / Inert atmosphere
1.2: 5 h / 0 - 20 °C / Cooling with ice
2.1: toluene / 5 h / 20 °C
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.47 h / -78 °C
3.2: 0.17 h / 20 °C
4.1: sodium periodate; sulfuric acid / ruthenium trichloride / acetonitrile; water / 0.25 h / 20 °C / Inert atmosphere
5.1: aminosulfonic acid; sodium chlorite; sulfuric acid / acetonitrile; water / 0.17 h / 20 °C
6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1.5 h / 20 °C
6.2: 1.05 h / 0 °C
7.1: xylene / 0.5 h / 120 °C
8.1: triphenylphosphine; diethylazodicarboxylate / toluene; tetrahydrofuran / 0.55 h / 20 °C
With
sodium chlorite; sodium periodate; sulfuric acid; aminosulfonic acid; sodium tert-pentoxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate;
ruthenium trichloride;
In
tetrahydrofuran; 1,3-dimethyl-2-imidazolidinone; water; N,N-dimethyl-formamide; toluene; acetonitrile; xylene;
