4-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl)-1-phenylthiosemicarbazide

Base Information

• Chemical Name: 4-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl)-1-phenylthiosemicarbazide
• CAS No.: 1312698-80-8
• Molecular Formula: C₁₅H₁₃N₅OS₂
• Molecular Weight: 343.433
• Mol file: 1312698-80-8.mol

Synonyms:4-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl)-1-phenylthiosemicarbazide

Chemical Property of 4-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl)-1-phenylthiosemicarbazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl)-1-phenylthiosemicarbazide

There total 4 articles about 4-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl)-1-phenylthiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylhydrazine (100-63-0) + 5-(4-isothiocyanatophenyl)-1,3,4-oxadiazole-2-thiol → 4-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl)-1-phenylthiosemicarbazide (1312698-80-8)

Guidance literature:

In toluene; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2011.04.017

Reference yield:

4-methoxycarbonyl aniline (619-45-4) → 4-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl)-1-phenylthiosemicarbazide (1312698-80-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrazine hydrate / 1 h / Reflux

2.1: potassium hydroxide / ethanol; N,N-dimethyl-formamide / 0 °C / Inert atmosphere; Reflux

2.2: pH 4

3.1: sodium hydrogencarbonate / acetone / 0.5 h / 0 - 20 °C

4.1: toluene / 20 °C / Inert atmosphere

With sodium hydrogencarbonate; hydrazine hydrate; potassium hydroxide; In ethanol; N,N-dimethyl-formamide; acetone; toluene;

DOI:10.1016/j.ejmech.2011.04.017

Reference yield:

4-aminobenzohydrazide (5351-17-7) → 4-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl)-1-phenylthiosemicarbazide (1312698-80-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium hydroxide / ethanol; N,N-dimethyl-formamide / 0 °C / Inert atmosphere; Reflux

1.2: pH 4

2.1: sodium hydrogencarbonate / acetone / 0.5 h / 0 - 20 °C

3.1: toluene / 20 °C / Inert atmosphere

With sodium hydrogencarbonate; potassium hydroxide; In ethanol; N,N-dimethyl-formamide; acetone; toluene;

DOI:10.1016/j.ejmech.2011.04.017

upstream raw materials:

5-(4-aminophenyl)-1,3,4-oxadiazole-2-thiol

phenylhydrazine

4-aminobenzohydrazide

4-methoxycarbonyl aniline