4-[(3-{[4-(4-Butyryl-5-methyl-1H-pyrazol-1-yl)phenyl]carbamoyl}-5-chloro-1H-indol-1-yl)acetyl]-1-methylpiperazine-2-carboxylic acid

Base Information

Chemical Name:4-[(3-{[4-(4-Butyryl-5-methyl-1H-pyrazol-1-yl)phenyl]carbamoyl}-5-chloro-1H-indol-1-yl)acetyl]-1-methylpiperazine-2-carboxylic acid
CAS No.:1404529-33-4
Molecular Formula:C₃₁H₃₃ClN₆O₅
Molecular Weight:605.093
Hs Code.:

Synonyms:4-[(3-{[4-(4-Butyryl-5-methyl-1H-pyrazol-1-yl)phenyl]carbamoyl}-5-chloro-1H-indol-1-yl)acetyl]-1-methylpiperazine-2-carboxylic acid

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Chemical Property of 4-[(3-{[4-(4-Butyryl-5-methyl-1H-pyrazol-1-yl)phenyl]carbamoyl}-5-chloro-1H-indol-1-yl)acetyl]-1-methylpiperazine-2-carboxylic acid

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Technology Process of 4-[(3-{[4-(4-Butyryl-5-methyl-1H-pyrazol-1-yl)phenyl]carbamoyl}-5-chloro-1H-indol-1-yl)acetyl]-1-methylpiperazine-2-carboxylic acid

There total 2 articles about 4-[(3-{[4-(4-Butyryl-5-methyl-1H-pyrazol-1-yl)phenyl]carbamoyl}-5-chloro-1H-indol-1-yl)acetyl]-1-methylpiperazine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1404529-32-3
methyl 4-(2-(3-{[4-(4-butyryl-5-methyl-1H-pyrazol-1-yl)phenyl]carbamoyl}-5-chloro-1H-indol-1-yl)acetyl)-1-methylpiperazine-2-carboxylate

: 1404529-33-4
4-[(3-{[4-(4-Butyryl-5-methyl-1H-pyrazol-1-yl)phenyl]carbamoyl}-5-chloro-1H-indol-1-yl)acetyl]-1-methylpiperazine-2-carboxylic acid

Guidance literature:: methyl 4-(2-(3-{[4-(4-butyryl-5-methyl-1H-pyrazol-1-yl)phenyl]carbamoyl}-5-chloro-1H-indol-1-yl)acetyl)-1-methylpiperazine-2-carboxylate; With methanol; sodium hydrogencarbonate; for 18h;

With hydrogenchloride; In water;

Reference yield:

: 1404538-71-1
C₃₁H₃₃ClN₆O₅

: 1404529-33-4
4-[(3-{[4-(4-Butyryl-5-methyl-1H-pyrazol-1-yl)phenyl]carbamoyl}-5-chloro-1H-indol-1-yl)acetyl]-1-methylpiperazine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: formic acid / water / 50 - 70 °C

2: sodium hydrogencarbonate; methanol / 18 h

With methanol; formic acid; sodium hydrogencarbonate; In water;

Reference yield:

: 1404529-33-4
4-[(3-{[4-(4-Butyryl-5-methyl-1H-pyrazol-1-yl)phenyl]carbamoyl}-5-chloro-1H-indol-1-yl)acetyl]-1-methylpiperazine-2-carboxylic acid

: 74-89-5
methylamine

: N-[4-(4-butyryl-5-methyl-1H-pyrazol-1-yl)phenyl]-5-chloro-1-{2-[4-methyl-3-(methylcarbamoyl)piperazin-1-yl]-2-oxoethyl}-1H-indole-3-carboxamide hydrochloride

Guidance literature:: 4-[(3-{[4-(4-Butyryl-5-methyl-1H-pyrazol-1-yl)phenyl]carbamoyl}-5-chloro-1H-indol-1-yl)acetyl]-1-methylpiperazine-2-carboxylic acid; With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; at -10 ℃; for 2h;

methylamine; In tetrahydrofuran; at -10 - 20 ℃; for 15h;

With hydrogenchloride; In methanol; diethyl ether; acetone;