2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[2-(1-hydroxyethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

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Chemical Name:2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[2-(1-hydroxyethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide
CAS No.:1301660-47-8
Molecular Formula:C₃₁H₃₀F₇N₃O₃
Molecular Weight:625.586
Hs Code.:

Synonyms:2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[2-(1-hydroxyethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

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Chemical Property of 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[2-(1-hydroxyethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

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Technology Process of 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[2-(1-hydroxyethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

There total 10 articles about 2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[2-(1-hydroxyethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1301661-12-0
N-[6-(2-acetyl-5-oxo-3-pyrrolidinyl)-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide

: 1301660-47-8
2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[2-(1-hydroxyethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

Guidance literature:: N-[6-(2-acetyl-5-oxo-3-pyrrolidinyl)-4-(4-fluoro-2-methylphenyl)-3-pyridinyl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide; With sodium tetrahydroborate; In ethanol; at 20 ℃; for 1h;

With ammonium chloride; In water; ethyl acetate;

Reference yield:

: 825643-73-0
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide

: 1301660-47-8
2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[2-(1-hydroxyethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 8 h / Reflux

2.1: osmium(VIII) oxide; water / tetrahydrofuran / 0.5 h / 20 °C

2.2: 4 h / 20 °C

3.1: toluene / 2 h / Reflux

4.1: sodium ethanolate / ethanol; dimethyl sulfoxide / 0.5 h / 20 °C

4.2: 18 h / 110 °C

5.1: sodium hydroxide; water / methanol / 18 h / 20 °C

6.1: toluene; dimethyl sulfoxide / 3 h / 100 °C

7.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.17 h / 140 °C / Microwave irradiation

8.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 20 °C

9.1: diethyl ether; tetrahydrofuran / 0 - 20 °C

10.1: sodium tetrahydroborate / ethanol / 1 h / 20 °C

With 4-methyl-morpholine; sodium tetrahydroborate; osmium(VIII) oxide; water; sodium ethanolate; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene; 1.1: Suzuki Coupling;

Reference yield:

: 1301660-56-9
2-[3,5-bis(trifluoromethyl)phenyl]-N-[4-(4-fluoro-2-methylphenyl)-6-formyl-3-pyridinyl]-N,2-dimethylpropanamide

: 1301660-47-8
2-[3,5-bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[2-(1-hydroxyethyl)-5-oxo-3-pyrrolidinyl]-3-pyridinyl}-N,2-dimethylpropanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene / 2 h / Reflux

2.1: sodium ethanolate / ethanol; dimethyl sulfoxide / 0.5 h / 20 °C

2.2: 18 h / 110 °C

3.1: sodium hydroxide; water / methanol / 18 h / 20 °C

4.1: toluene; dimethyl sulfoxide / 3 h / 100 °C

5.1: water; lithium hydroxide / tetrahydrofuran; methanol / 0.17 h / 140 °C / Microwave irradiation

6.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 20 °C

7.1: diethyl ether; tetrahydrofuran / 0 - 20 °C

8.1: sodium tetrahydroborate / ethanol / 1 h / 20 °C

With 4-methyl-morpholine; sodium tetrahydroborate; water; sodium ethanolate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; toluene;