benzyl (2-amino-9-((2R,3R,4R,5R)-4-(((benzyloxy)carbonyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluoro-3-methyltetrahydrofuran-2-yl)-9H-purin-6-yl)carbamate

Base Information

Chemical Name:benzyl (2-amino-9-((2R,3R,4R,5R)-4-(((benzyloxy)carbonyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluoro-3-methyltetrahydrofuran-2-yl)-9H-purin-6-yl)carbamate
CAS No.:1412427-27-0
Molecular Formula:C₃₃H₄₁FN₆O₇Si
Molecular Weight:680.808
Hs Code.:

benzyl (2-amino-9-((2R,3R,4R,5R)-4-(((benzyloxy)carbonyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluoro-3-methyltetrahydrofuran-2-yl)-9H-purin-6-yl)carbamate

Synonyms:benzyl (2-amino-9-((2R,3R,4R,5R)-4-(((benzyloxy)carbonyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluoro-3-methyltetrahydrofuran-2-yl)-9H-purin-6-yl)carbamate

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Chemical Property of benzyl (2-amino-9-((2R,3R,4R,5R)-4-(((benzyloxy)carbonyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluoro-3-methyltetrahydrofuran-2-yl)-9H-purin-6-yl)carbamate

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Technology Process of benzyl (2-amino-9-((2R,3R,4R,5R)-4-(((benzyloxy)carbonyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluoro-3-methyltetrahydrofuran-2-yl)-9H-purin-6-yl)carbamate

There total 3 articles about benzyl (2-amino-9-((2R,3R,4R,5R)-4-(((benzyloxy)carbonyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluoro-3-methyltetrahydrofuran-2-yl)-9H-purin-6-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1412427-26-9
(2R,3R,4R,5R)-2-(((tert-bulyldimethylsilyl)oxy)methyl)-5-(2,6-diamino-9H-purin-9-yl)-4-fluoro-4-methyltetrahydrofuran-3-ol

: 501-53-1,94274-21-2
benzyl chloroformate

: 1412427-27-0
benzyl (2-amino-9-((2R,3R,4R,5R)-4-(((benzyloxy)carbonyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluoro-3-methyltetrahydrofuran-2-yl)-9H-purin-6-yl)carbamate

Guidance literature:: dmap; In dichloromethane; at 20 ℃;

Reference yield:

: ((2R,3R,4R,5R)-5-(2,6-diamino-9H-purin-9-yl)-4-fluoro-2-(hydroxymethyl)-4-methyltetrahydrofuran-3-ol)

: 1412427-27-0
benzyl (2-amino-9-((2R,3R,4R,5R)-4-(((benzyloxy)carbonyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluoro-3-methyltetrahydrofuran-2-yl)-9H-purin-6-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: dmap / dichloromethane / 20 °C

With pyridine; dmap; In dichloromethane;

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1412427-27-0
benzyl (2-amino-9-((2R,3R,4R,5R)-4-(((benzyloxy)carbonyl)oxy)-5-(((tert-butyldimethylsilyl)oxy)methyl)-3-fluoro-3-methyltetrahydrofuran-2-yl)-9H-purin-6-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine

2: dmap / dichloromethane / 20 °C

With pyridine; dmap; In dichloromethane;