tert-butyl (6R)-6-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

Base Information

Chemical Name:tert-butyl (6R)-6-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate
CAS No.:1092938-82-3
Molecular Formula:C₂₃H₂₇BrN₂O₄
Molecular Weight:475.382
Hs Code.:

Synonyms:tert-butyl (6R)-6-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (6R)-6-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

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Technology Process of tert-butyl (6R)-6-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

There total 8 articles about tert-butyl (6R)-6-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1073630-53-1
(6R)-6-hydroxyheptanoic acid tert.-butyl ester

: 1073135-81-5
5-bromo-4-chloro-6-phenylfuro[2,3-d]pyrimidine

: 1092938-82-3
tert-butyl (6R)-6-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃;

Reference yield:

: 1073630-51-9
(2E,6R)-6-hydroxyhept-2-enoic acid tert.-butyl ester

: 1092938-82-3
tert-butyl (6R)-6-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 760.05 Torr

2: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C

With hydrogen; sodium hydride; palladium 10% on activated carbon; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 62327-21-3
tert-butyl dimethylphosphonoacetate

: 1092938-82-3
tert-butyl (6R)-6-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]heptanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / 20 °C / Cooling

1.2: -78 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h / 20 °C / 760.05 Torr

3.1: sodium hydride / N,N-dimethyl-formamide / 0.75 h / 0 - 20 °C

With hydrogen; sodium hydride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;