N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)benzenesulfonamide

Base Information

Chemical Name:N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)benzenesulfonamide
CAS No.:1217272-87-1
Molecular Formula:C₂₅H₂₂N₆O₅S
Molecular Weight:518.553
Hs Code.:

Synonyms:N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)benzenesulfonamide

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Chemical Property of N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)benzenesulfonamide

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Technology Process of N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)benzenesulfonamide

There total 3 articles about N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1192749-74-8
N-(5-bromopyridin-3-yl)-N-(phenylsulfonyl)benzenesulfonamide

: 1217272-70-2
7-(4-methoxyphenyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

: 1217272-87-1
N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: N-(5-bromopyridin-3-yl)-N-(phenylsulfonyl)benzenesulfonamide; 7-(4-methoxyphenyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione; With copper(l) iodide; palladium diacetate; caesium carbonate; In N,N-dimethyl-formamide; at 130 - 140 ℃; for 40h; Inert atmosphere; Sealed tube;

With water; In dichloromethane; N,N-dimethyl-formamide; Inert atmosphere;
DOI:10.1021/ol100011n

Reference yield:

: 58-55-9,75448-53-2
theophylline

: 1217272-87-1
N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; copper diacetate / dichloromethane / 24 h / 40 °C / Inert atmosphere

2: copper(l) iodide; palladium diacetate; caesium carbonate / N,N-dimethyl-formamide / 40 h / 130 °C / Inert atmosphere

With pyridine; copper(l) iodide; copper diacetate; palladium diacetate; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.025

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 1217272-87-1
N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; copper diacetate / dichloromethane / 24 h / 40 °C / Inert atmosphere

2: copper(l) iodide; palladium diacetate; caesium carbonate / N,N-dimethyl-formamide / 40 h / 130 °C / Inert atmosphere

With pyridine; copper(l) iodide; copper diacetate; palladium diacetate; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.025