{2-[6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enyl]-ethyl}-(1-ethoxy-2-methyl-propyl)-carbamic acid ethyl ester

Base Information

• Chemical Name: {2-[6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enyl]-ethyl}-(1-ethoxy-2-methyl-propyl)-carbamic acid ethyl ester
• CAS No.: 341497-49-2
• Molecular Formula: C₃₃H₄₉NO₄Si
• Molecular Weight: 551.842
• Mol file: 341497-49-2.mol

Synonyms:{2-[6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enyl]-ethyl}-(1-ethoxy-2-methyl-propyl)-carbamic acid ethyl ester

Chemical Property of {2-[6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enyl]-ethyl}-(1-ethoxy-2-methyl-propyl)-carbamic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {2-[6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enyl]-ethyl}-(1-ethoxy-2-methyl-propyl)-carbamic acid ethyl ester

There total 4 articles about {2-[6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enyl]-ethyl}-(1-ethoxy-2-methyl-propyl)-carbamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

{2-[(R)-6-(tert-Butyl-diphenyl-silanyloxy)-cyclohex-1-enyl]-ethyl}-[2-methyl-prop-(E)-ylidene]-amine + diethyl dicarbonate (1609-47-8) → {2-[6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enyl]-ethyl}-(1-ethoxy-2-methyl-propyl)-carbamic acid ethyl ester (341497-49-2)

Guidance literature:

In ethanol; at 20 ℃; for 24h;

DOI:10.1021/ol015696v

Reference yield:

tert-butyl(2-iodocyclohex-2-enyloxy)diphenylsilane → {2-[6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enyl]-ethyl}-(1-ethoxy-2-methyl-propyl)-carbamic acid ethyl ester (341497-49-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 84 percent / (9-BBN)2; NaOH / PdCl₂(dppf) / tetrahydrofuran

2: 100 percent / Pd on carbon; NH₄HCO₂; AcOH / methanol / 1 h / 20 °C

3: MgSO₄; K₂CO₃ / CH₂Cl₂ / 20 °C

4: 85 percent / ethanol / 24 h / 20 °C

With sodium hydroxide; palladium on activated charcoal; 9-borabicyclo[3.3.1]nonane dimer; ammonium formate; magnesium sulfate; potassium carbonate; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; ethanol; dichloromethane;

DOI:10.1021/ol015696v

Reference yield:

(R)-2-[6'-(tert-butyldiphenylsiloxy)-1'-cyclohexen-1'-yl]ethylamine (341497-33-4) → {2-[6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enyl]-ethyl}-(1-ethoxy-2-methyl-propyl)-carbamic acid ethyl ester (341497-49-2)

Guidance literature:

Multi-step reaction with 2 steps

1: MgSO₄; K₂CO₃ / CH₂Cl₂ / 20 °C

2: 85 percent / ethanol / 24 h / 20 °C

With magnesium sulfate; potassium carbonate; In ethanol; dichloromethane;

DOI:10.1021/ol015696v

upstream raw materials:

diethyl dicarbonate

(R)-2-[6'-(tert-butyldiphenylsiloxy)-1'-cyclohexen-1'-yl]ethylamine

benzyl 2-[(6'R)-(tert-butyldiphenylsiloxy)cyclohex-1-enyl]ethylcarbamate