(R)-2-[6'-(tert-butyldiphenylsiloxy)-1'-cyclohexen-1'-yl]ethylamine

Base Information

• Chemical Name: (R)-2-[6'-(tert-butyldiphenylsiloxy)-1'-cyclohexen-1'-yl]ethylamine
• CAS No.: 341497-33-4
• Molecular Formula: C₂₄H₃₃NOSi
• Molecular Weight: 379.618
• Mol file: 341497-33-4.mol

Synonyms:(R)-2-[6'-(tert-butyldiphenylsiloxy)-1'-cyclohexen-1'-yl]ethylamine

Chemical Property of (R)-2-[6'-(tert-butyldiphenylsiloxy)-1'-cyclohexen-1'-yl]ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-[6'-(tert-butyldiphenylsiloxy)-1'-cyclohexen-1'-yl]ethylamine

There total 2 articles about (R)-2-[6'-(tert-butyldiphenylsiloxy)-1'-cyclohexen-1'-yl]ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

benzyl 2-[(6'R)-(tert-butyldiphenylsiloxy)cyclohex-1-enyl]ethylcarbamate (252765-94-9) → (R)-2-[6'-(tert-butyldiphenylsiloxy)-1'-cyclohexen-1'-yl]ethylamine (341497-33-4)

Guidance literature:

With palladium on activated charcoal; ammonium formate; acetic acid; In methanol; at 20 ℃; for 1h;

DOI:10.1021/ol015696v

Reference yield:

tert-butyl(2-iodocyclohex-2-enyloxy)diphenylsilane → (R)-2-[6'-(tert-butyldiphenylsiloxy)-1'-cyclohexen-1'-yl]ethylamine (341497-33-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / (9-BBN)2; NaOH / PdCl₂(dppf) / tetrahydrofuran

2: 100 percent / Pd on carbon; NH₄HCO₂; AcOH / methanol / 1 h / 20 °C

With sodium hydroxide; palladium on activated charcoal; 9-borabicyclo[3.3.1]nonane dimer; ammonium formate; acetic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol;

DOI:10.1021/ol015696v

Reference yield:

(R)-2-[6'-(tert-butyldiphenylsiloxy)-1'-cyclohexen-1'-yl]ethylamine (341497-33-4) + isobutyraldehyde (78-84-2) → {2-[(R)-6-(tert-Butyl-diphenyl-silanyloxy)-cyclohex-1-enyl]-ethyl}-[2-methyl-prop-(E)-ylidene]-amine

Guidance literature:

With magnesium sulfate; potassium carbonate; In dichloromethane; at 20 ℃;

DOI:10.1021/ol015696v

upstream raw materials:

benzyl 2-[(6'R)-(tert-butyldiphenylsiloxy)cyclohex-1-enyl]ethylcarbamate

Downstream raw materials:

{2-[6-(tert-butyl-diphenyl-silanyloxy)-cyclohex-1-enyl]-ethyl}-(1-ethoxy-2-methyl-propyl)-carbamic acid ethyl ester