1-(2-chloroethyl)-3-(1-(5-cyano-2-(3,5-dichlorophenoxy)-phenylsulfonyl)piperidin-4-yl)urea

Base Information

Chemical Name:1-(2-chloroethyl)-3-(1-(5-cyano-2-(3,5-dichlorophenoxy)-phenylsulfonyl)piperidin-4-yl)urea
CAS No.:1334523-64-6
Molecular Formula:C₂₁H₂₁Cl₃N₄O₄S
Molecular Weight:531.847
Hs Code.:

Synonyms:1-(2-chloroethyl)-3-(1-(5-cyano-2-(3,5-dichlorophenoxy)-phenylsulfonyl)piperidin-4-yl)urea

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Chemical Property of 1-(2-chloroethyl)-3-(1-(5-cyano-2-(3,5-dichlorophenoxy)-phenylsulfonyl)piperidin-4-yl)urea

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Technology Process of 1-(2-chloroethyl)-3-(1-(5-cyano-2-(3,5-dichlorophenoxy)-phenylsulfonyl)piperidin-4-yl)urea

There total 5 articles about 1-(2-chloroethyl)-3-(1-(5-cyano-2-(3,5-dichlorophenoxy)-phenylsulfonyl)piperidin-4-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1943-83-5
2-chloroethyl isothiocyanate

: 1334523-88-4
3-(4-aminopiperidin-1-ylsulfonyl)-4-(3,5-dichlorophenoxy)benzonitrile

: 1334523-64-6
1-(2-chloroethyl)-3-(1-(5-cyano-2-(3,5-dichlorophenoxy)-phenylsulfonyl)piperidin-4-yl)urea

Guidance literature:: With triethylamine; In tetrahydrofuran; for 1h;

Reference yield:

: 73874-95-0
(piperidin-4-yl)carbamic acid tert-butyl ester

: 1334523-64-6
1-(2-chloroethyl)-3-(1-(5-cyano-2-(3,5-dichlorophenoxy)-phenylsulfonyl)piperidin-4-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / tetrahydrofuran / 1 h / 20 °C

2.1: potassium carbonate; 18-crown-6 ether / tetrahydrofuran / 96 h / Reflux

3.1: trifluoroacetic acid / dichloromethane / 22 h

3.2: pH 7

4.1: triethylamine / tetrahydrofuran / 1 h

With 18-crown-6 ether; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1334523-89-5
C₁₇H₂₂ClN₃O₄S

: 1334523-64-6
1-(2-chloroethyl)-3-(1-(5-cyano-2-(3,5-dichlorophenoxy)-phenylsulfonyl)piperidin-4-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; 18-crown-6 ether / tetrahydrofuran / 96 h / Reflux

2.1: trifluoroacetic acid / dichloromethane / 22 h

2.2: pH 7

3.1: triethylamine / tetrahydrofuran / 1 h

With 18-crown-6 ether; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;