(R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid acid sodium salt

Base Information

• Chemical Name: (R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid acid sodium salt
• CAS No.: 1266162-63-3
• Molecular Formula: C₁₅H₁₈ClO₄S*Na
• Molecular Weight: 352.814
• Mol file: 1266162-63-3.mol

Synonyms:(R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid acid sodium salt

Chemical Property of (R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid acid sodium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid acid sodium salt

There total 11 articles about (R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid Sodium Salt (1265819-87-1) → (R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid acid sodium salt (1266162-63-3)

Guidance literature:

With hydrogen; (S)-Me-f-Ketalphos; In tetrahydrofuran; at 50 ℃; for 17h; under 37503.8 Torr; Autoclave;

Reference yield:

(E)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid Sodium Salt (1265819-87-1) → (R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid acid sodium salt (1266162-63-3) + (S)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid acid sodium salt

Guidance literature:

With hydrogen; [Ir(COD)((R)-3,5-iPr-MeOBIPHEP)]BF₄; In dichloromethane; ethylene glycol; at 50 ℃; for 17h; under 15001.5 Torr;

Reference yield:

(3-chloro-4-methylsulfanyl-phenyl)-acetic acid (87776-75-8) → (R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid acid sodium salt (1266162-63-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: dihydrogen peroxide / water; formic acid / 22 h / 50 °C

2.1: acetic anhydride; sodium acetate / tetrahydrofuran / 24 h / 40 °C

2.2: 2 h / 40 °C

2.3: pH 6 / Cooling with ice

3.1: acetone / 22 h / 0 - 20 °C

4.1: hydrogenchloride / dichloromethane; water

4.2: 20 - 50 °C

5.1: hydrogen / (S)-Me-f-Ketalphos / tetrahydrofuran / 17 h / 50 °C / 37503.8 Torr / Autoclave

With hydrogenchloride; hydrogen; dihydrogen peroxide; sodium acetate; acetic anhydride; (S)-Me-f-Ketalphos; In tetrahydrofuran; formic acid; dichloromethane; water; acetone;

upstream raw materials:

(3-chloro-4-methylsulfanyl-phenyl)-acetic acid

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid

(3-Chloro-4-methanesulfonyl-phenyl)acetic acid

(E)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid Sodium Salt

Downstream raw materials:

(R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid