(E)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid Sodium Salt

Base Information

• Chemical Name: (E)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid Sodium Salt
• CAS No.: 1265819-87-1
• Molecular Formula: C₁₅H₁₆ClO₄S*Na
• Molecular Weight: 350.798
• Mol file: 1265819-87-1.mol

Synonyms:(E)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid Sodium Salt

Chemical Property of (E)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid Sodium Salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid Sodium Salt

There total 5 articles about (E)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid Sodium Salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid dicyclohexylamine salt (1265819-85-9) → (E)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid Sodium Salt (1265819-87-1)

Guidance literature:

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid dicyclohexylamine salt; With hydrogenchloride; In dichloromethane; water;

With sodium methylate; In methanol; isopropyl alcohol; at 20 - 50 ℃;

Reference yield:

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid (345635-33-8) → (E)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid Sodium Salt (1265819-87-1)

Guidance literature:

With sodium methylate; In isopropyl alcohol; at 50 ℃;

Reference yield:

(3-chloro-4-methylsulfanyl-phenyl)-acetic acid (87776-75-8) → (E)-2-(3-Chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid Sodium Salt (1265819-87-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dihydrogen peroxide / water; formic acid / 22 h / 50 °C

2.1: acetic anhydride; sodium acetate / tetrahydrofuran / 24 h / 40 °C

2.2: 2 h / 40 °C

2.3: pH 6 / Cooling with ice

3.1: acetone / 22 h / 0 - 20 °C

4.1: hydrogenchloride / dichloromethane; water

4.2: 20 - 50 °C

With hydrogenchloride; dihydrogen peroxide; sodium acetate; acetic anhydride; In tetrahydrofuran; formic acid; dichloromethane; water; acetone;

upstream raw materials:

(3-chloro-4-methylsulfanyl-phenyl)-acetic acid

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid

(3-Chloro-4-methanesulfonyl-phenyl)acetic acid

(E)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-acrylic acid dicyclohexylamine salt

Downstream raw materials:

(R)-2-(3-chloro-4-(methylsulfonyl)phenyl)-3-cyclopentylpropanoic acid

(R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-cyclopentyl-propionic acid acid sodium salt