2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (E)-3-phenyl-2-propenoate

Base Information

Chemical Name:2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (E)-3-phenyl-2-propenoate
CAS No.:548739-97-5
Molecular Formula:C₁₉H₁₄F₆O₄S
Molecular Weight:452.374
Hs Code.:

Synonyms:2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (E)-3-phenyl-2-propenoate

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Chemical Property of 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (E)-3-phenyl-2-propenoate

Chemical Property:

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Technology Process of 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (E)-3-phenyl-2-propenoate

There total 6 articles about 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (E)-3-phenyl-2-propenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 140-10-3
(E)-3-phenylacrylic acid

: 450409-87-7
2-[3,5-bis(trifluoromethyl)phenylsulfonyl]-1-ethanol

: 548739-97-5
2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (E)-3-phenyl-2-propenoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1055/s-2003-36844

Reference yield:

: 130783-02-7
3,5-bis(trifluoromethyl)thiophenol

: 548739-97-5
2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (E)-3-phenyl-2-propenoate

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / Et₃N / acetonitrile / 24 h / 20 °C

2: MnSO₄; aq. H₂O₂; NaHCO₃ / acetonitrile / 20 °C

3: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; DMAP / CH₂Cl₂ / 12 h / 20 °C

With dmap; manganese(II) sulfate; dihydrogen peroxide; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1055/s-2003-36844

Reference yield:

: 450409-97-9
2-[3,5-di(trifluoromethyl)phenylsulfanyl]-1-ethanol

: 548739-97-5
2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl (E)-3-phenyl-2-propenoate

Guidance literature:: Multi-step reaction with 2 steps

1: MnSO₄; aq. H₂O₂; NaHCO₃ / acetonitrile / 20 °C

2: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; DMAP / CH₂Cl₂ / 12 h / 20 °C

With dmap; manganese(II) sulfate; dihydrogen peroxide; sodium hydrogencarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile;
DOI:10.1055/s-2003-36844