N-[3-(2-bromoacetyl)-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methyl-acetamide

Base Information

Chemical Name:N-[3-(2-bromoacetyl)-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methyl-acetamide
CAS No.:1178584-47-8
Molecular Formula:C₁₁H₈BrF₈NO₂S
Molecular Weight:450.147
Hs Code.:

Synonyms:N-[3-(2-bromoacetyl)-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methyl-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[3-(2-bromoacetyl)-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methyl-acetamide

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Technology Process of N-[3-(2-bromoacetyl)-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methyl-acetamide

There total 10 articles about N-[3-(2-bromoacetyl)-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methyl-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1178584-95-6
N-[3-acetyl-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methylacetamide

: 1178584-47-8
N-[3-(2-bromoacetyl)-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methyl-acetamide

Guidance literature:: With phenyltrimethylammonium tribromide; In tetrahydrofuran; methanol; at 20 - 60 ℃;

Reference yield:

: 833-96-5
3-(pentafluoro-λ⁶-sulphanyl)benzoic acid

: 1178584-47-8
N-[3-(2-bromoacetyl)-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methyl-acetamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: nitric acid; sulfuric acid / 75 °C

2.1: thionyl chloride / dichloromethane / 20 °C / Reflux

3.1: N,N-diethyl-N-isopropylamine / dichloromethane / 1 h / 20 °C

4.1: hydrogen / Raney nickel / methanol / 5 h

5.1: triethylamine / dichloromethane / 20 °C

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

6.2: 2 h / 20 °C / Cooling with ice

6.3: Cooling

7.1: potassium carbonate / 1,2-dimethoxyethane / 0.67 h / 100 °C / microwave irradiation

8.1: phenyltrimethylammonium tribromide / tetrahydrofuran; methanol / 20 - 60 °C

With thionyl chloride; N,N-diethyl-N-isopropylamine; sulfuric acid; hydrogen; nitric acid; phenyltrimethylammonium tribromide; potassium carbonate; triethylamine; lithium hexamethyldisilazane; Raney nickel; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: C₇H₃ClF₅NO₃S

: 1178584-47-8
N-[3-(2-bromoacetyl)-5-(pentafluorosulfanyl)phenyl]-2,2,2-trifluoro-N-methyl-acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: N,N-diethyl-N-isopropylamine / dichloromethane / 1 h / 20 °C

2.1: hydrogen / Raney nickel / methanol / 5 h

3.1: triethylamine / dichloromethane / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C

4.2: 2 h / 20 °C / Cooling with ice

4.3: Cooling

5.1: potassium carbonate / 1,2-dimethoxyethane / 0.67 h / 100 °C / microwave irradiation

6.1: phenyltrimethylammonium tribromide / tetrahydrofuran; methanol / 20 - 60 °C

With N,N-diethyl-N-isopropylamine; hydrogen; phenyltrimethylammonium tribromide; potassium carbonate; triethylamine; lithium hexamethyldisilazane; Raney nickel; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane;